Pathogenesis and long-term prognosis of Kawasaki disease : New therapeutic strategy using vasogenesis therapy

川崎病的发病机制和长期预后：血管生成疗法的新治疗策略

• 批准号: 16591066
• 负责人: ISHII Masahiro
• 金额: $ 2.37万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591066/
• 关键词: Kawasaki disease; coronary aneurysm; angiogenesis; endothelial function; genetic profile; vitamin C; angiotensin 1; molecular genetics; 薬物負荷; 血管内皮機; RNA; 遺伝子

Kawasaki disease (KD) is an acute, self limiting systemic vasculitis syndrome of unknown origin that mainly affects small and medium-sized arteries, particularly the coronary artery. From 3-8% of children develop coronary artery lesions (CALs) after intravenous immunoglobulin (IVIG) therapy, and approximately 4% of KD children develop ischemic heart disease with myocardial infarction. On the basis of clinical features and epidemiological data, KD might be caused by very common infectious agents in some susceptible hosts. We investigated the difference of gene expression between patients with KD and control subjects by use the Affymetrix GeneChip system. Some genetic factors might participate in pathogenesis of KD, and some angiogenesis factors might concern in incidence of CAL. The cardiovascular spectrum of 2180 patients with acute KD experienced over the last 30 years. Of all the patients, 14.9% were diagnosed as having CALs. From 1991 we started IVIG treatment, since then the incidence of CALs has declined to 8.7%. Myocardial infarction occurred in 24 patients, 7 of whom died. Long-term follow-up study is necessary in KD patients, and should pay attention to the possible development of premature atherosclerosis.

川崎疾病（KD）是一种急性，自我限制的全身性血管炎综合征，主要影响中小型动脉，尤其是冠状动脉。静脉免疫球蛋白（IVIG）治疗后，从3-8％的儿童开始患冠状动脉病变（CAL），大约4％的KD儿童患有心肌梗塞患缺血性心脏病。在临床特征和流行病学数据的基础上，KD可能是由于某些易感宿主中非常常见的传染剂引起的。我们通过使用Affymetrix Genechip系统研究了KD患者和对照组患者之间基因表达的差异。某些遗传因素可能参与KD的发病机理，并且某些血管生成因子可能会涉及CAL的发生率。在过去30年中，有2180例急性KD患者的心血管谱。在所有患者中，有14.9％被诊断为患有CAL。从1991年开始，我们开始了IVIG治疗，从那时起，CAL的发病率下降到8.7％。 24例患者发生心肌梗塞，其中7例死亡。长期的随访研究是KD患者需要的，应注意早产性动脉粥样硬化的可能发展。

项目成果

川崎病:心臓ナビゲーター

川崎病：心脏导航器

• 发表时间: 2004
• 作者: Kawagoe R;et al.;石井正造
• 通讯作者: 石井正造

Kawasaki disease.

• DOI: 10.1148/radiology.203.1.218
• 发表时间: 1994
• 期刊: Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
• 作者: L. Jonides;C. Rudy;S. Walsh

Early Intravenous Gamma-gloulin Treatment for Kawasaki Disease : Form the 15 and 16 Nationwide Surveys in Japan.

川崎病的早期静脉注射丙种球蛋白治疗：来自日本第 15 次和第 16 次全国性调查。

• 发表时间: 2004
• 期刊: J Pediatr 144
• 作者: Muta H;Ishii M;MD;Egami K;Furui J;Sugahara Y;Akagi T;Nakamura Y;Yanagawa H;Matsuishi T
• 通讯作者: Matsuishi T

Serum sodium levels in patients with Kawasaki disease

• DOI: 10.1007/s00246-004-0789-z
• 发表时间: 2005-07-01
• 期刊: PEDIATRIC CARDIOLOGY
• 影响因子: 1.6
• 作者: Muta, H;Ishii, M;Matsuishi, T
• 通讯作者: Matsuishi, T

川崎病年長例の検討 : 第16回全国調査より

第16次全国调查的老年川崎病病例调查

• 发表时间: 2004
• 期刊: 日児誌 108
• 作者: 坂上尊彦;牟田広実;石井正浩;江上公康;古井潤;菅原洋子;赤木禎治;中村好一;柳川豊次郎
• 通讯作者: 柳川豊次郎