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Vascular remodeling in Kawasaki disease

川崎病的血管重塑

基本信息

批准号：
12670797
负责人：
ISHII Masahiro
金额：
$ 2.05万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670797/
关键词：
Kawasaki disease remodeling Cather intervention Globulin sreroid aneurysm endothelial function 動脈瘤

项目摘要

To investigate the long-term consequences of regressed and normal coronary artery after KD using follow-up coronary angiography and to evaluate the vascular function of those using intracoronary infusion of ACh and of ISDN. The long-term regressed coronary aneurysms after KD had abnormal vascular wall morphology and vascular dysfunction. These patients should be counseled to avoid potential risk factors for atherosclerosis and long-term follow-up is needed into adulthood. We compared the efficacy and safety of additional intravenous immune globulin (IVIG) therapy With steroid pulse therapy in IVIG-resistant Kawasaki disease patients. ransient dilatation of the coronary artery is observed during steroid pulse therapy, so that careful echocardiographic examination should be performed for those patients receiving steroid pulse therapy for the ake of early detection of coronary artery abnormalities. This study was undertaken to assess the sequential follow-up results of catheter intervention in Kawasaki disease (KD) using quantitative coronary angiography(QCA) and intravascular ultrasound (IVUS) imaging. The catheter intervention for coronary artery stenotic lesions in KD demonstrated significant therapeuticc effects in the short, term. The long-term efficacy of catheter intervention for KD is unclear. To verify this finding, more long-term follow-up studies should be needed. To verify this finding, more lng-term follow-up studies should be needed. This guideline is an update summary of the group members opinions on how to effectively and appropriately perform catheter interventional treatment in coronary obstructive disease in Kawasaki disease on the basis of the information regarding evaluation of the diagnosis and the therapy reported in Japan and overseas.

通过随访冠状动脉造影研究KD后冠状动脉退化和正常的长期后果，并评价冠状动脉内输注ACh和ISDN的血管功能。KD后远期消退的冠状动脉瘤存在血管壁形态异常和血管功能障碍。这些患者应被告知避免动脉粥样硬化的潜在危险因素，并需要长期随访至成年。我们比较了静脉注射免疫球蛋白（IVIG）治疗抵抗的川崎患者的疗效和安全性。在类固醇脉冲治疗期间观察到冠状动脉的一过性扩张，因此，对于接受类固醇脉冲治疗的患者，应进行仔细的超声心动图检查，以便早期发现冠状动脉异常。本研究采用定量冠状动脉造影（QCA）和血管内超声（IVUS）成像评估川崎病（KD）导管介入治疗的连续随访结果。导管介入治疗川崎病冠状动脉狭窄近期疗效显著。导管介入治疗KD的长期疗效尚不清楚。为了验证这一发现，需要更多的长期随访研究。为了证实这一发现，需要更多的长期随访研究。本指南是根据日本和海外报告的诊断和治疗评价信息，对川崎病冠状动脉阻塞性疾病如何有效和适当地进行导管介入治疗的小组成员意见的更新总结。