Vascular remodeling in Kawasaki disease

川崎病的血管重塑

基本信息

批准号：
12670797
负责人：
ISHII Masahiro
金额：
$ 2.05万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670797/
关键词：
Kawasaki disease remodeling Cather intervention Globulin sreroid aneurysm endothelial function 動脈瘤

项目摘要

To investigate the long-term consequences of regressed and normal coronary artery after KD using follow-up coronary angiography and to evaluate the vascular function of those using intracoronary infusion of ACh and of ISDN. The long-term regressed coronary aneurysms after KD had abnormal vascular wall morphology and vascular dysfunction. These patients should be counseled to avoid potential risk factors for atherosclerosis and long-term follow-up is needed into adulthood. We compared the efficacy and safety of additional intravenous immune globulin (IVIG) therapy With steroid pulse therapy in IVIG-resistant Kawasaki disease patients. ransient dilatation of the coronary artery is observed during steroid pulse therapy, so that careful echocardiographic examination should be performed for those patients receiving steroid pulse therapy for the ake of early detection of coronary artery abnormalities. This study was undertaken to assess the sequential follow-up results of catheter intervention in Kawasaki disease (KD) using quantitative coronary angiography(QCA) and intravascular ultrasound (IVUS) imaging. The catheter intervention for coronary artery stenotic lesions in KD demonstrated significant therapeuticc effects in the short, term. The long-term efficacy of catheter intervention for KD is unclear. To verify this finding, more long-term follow-up studies should be needed. To verify this finding, more lng-term follow-up studies should be needed. This guideline is an update summary of the group members opinions on how to effectively and appropriately perform catheter interventional treatment in coronary obstructive disease in Kawasaki disease on the basis of the information regarding evaluation of the diagnosis and the therapy reported in Japan and overseas.

使用随访冠状动脉造影研究KD后回落和正常冠状动脉的长期后果，并评估使用冠状动脉内输注ACH和ISDN的血管功能。 KD后的长期退化的冠状动脉瘤具有异常的血管壁形态和血管功能障碍。应咨询这些患者，以避免动脉粥样硬化的潜在危险因素，并需要长期随访。我们将额外的静脉免疫球蛋白（IVIG）治疗与类固醇脉搏治疗在抗IVIG抗IVIG抗川崎病患者中的疗效和安全性。在类固醇脉搏治疗期间观察到冠状动脉的罕见扩张，因此，应对接受类固醇脉搏治疗的患者进行仔细的超声心动图检查，以便早期发现冠状动脉异常。进行了这项研究以评估使用定量冠状动脉造影（QCA）和血管内超声（IVUS）成像的川崎疾病（KD）导管干预的顺序随访结果。 KD中冠状动脉狭窄病变的导管干预在短期内表现出显着的治疗作用。导管干预KD的长期疗效尚不清楚。为了验证这一发现，应该需要更多的长期随访研究。为了验证这一发现，应该需要更多的LNG期随访研究。该指南是对小组成员对如何有效和适当进行川崎病中冠状动脉阻塞性疾病中导管介入治疗的意见的更新摘要，请根据评估日本和海外报告的诊断和疗法的信息。