Mechanism of the ability of atypical antipsychotic drugs to improve working memory and social function in schizophrenia

非典型抗精神病药物改善精神分裂症工作记忆和社会功能的机制

• 批准号: 16591126
• 负责人: SUMIYOSHI Tomiki
• 金额: $ 2.3万
• 依托单位: University of Toyama (2005-2006)Toyama Medical and Pharmaceutical University (2004)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591126/
• 关键词: atypical antipsychotic drug; schizophrenia; cognitive function; QOL; verbal learning and memory; verbal fluency; event-related potential; functional brain imaging; 不飽和脂肪酸; クオリティー・オブ・ライフ; 言語記憶; 記憶の体制化; セロトニン; ワーキングメモリー; 生物学的マーカー

The authors investigated the effect of atypical antipsychotic drugs (AAPDs) on cognitive function in patients with schizophrenia. We found that monotherapy with olanzapine (OLZ) or perospirone was associated with improvements in attention and quality of life in these patients.The effect of ziprasidone and OLZ on memory organization in patients with schizophrenia was studied. The multidimensional scaling (MDS) analysis was used to convert the order of verbal outputs from the. Category Fluency Task with "ANIMAL" names into a cognitive map representing organization of long-term semantic memory. Treatment with either drug resulted in appearance of semantically meaningful clusters, such as "wild vs. domesticity," which was not evident before treatment in subjects with schizophrenia. There was also an improvement in quality of life in these patients.We investigated the anatomical distribution of P300 current source density, by means of Low Resolution Electromagnetic Tomography (LORETA), before and after treatment with OLZ in subjects with schizophrenia. Normal control subjects demonstrated a left dominant laterality of P300 current density in the temporal regions, while this pattern was not evident in subjects with schizophrenia. Treatment with OLZ for 6 months restored the left dominant laterality pattern of P300 current density, which was accompanied with improvements in verbal learning memory, quality of life, and psychopathology, in the patients. The results of this study provides the first demonstration that the ability of some AAPDs to treat memory deficits of schizophrenia is likely to be associated with the change in the anatomical distribution of electrophysiological activity.

探讨非典型抗精神病药物(AAPD)对精神分裂症患者认知功能的影响。我们发现，单用奥氮平(OLZ)或培螺酮治疗可以改善这些患者的注意力和生活质量。我们研究了齐拉西酮和OLZ对精神分裂症患者记忆组织的影响。多维标度(MDS)分析被用来转换语言输出的顺序。将“动物”名称的类别流畅性任务编入代表长期语义记忆组织的认知图谱。任何一种药物的治疗都会导致语义上有意义的簇的出现，比如在精神分裂症受试者治疗之前，这一点并不明显。我们采用低分辨率电磁断层扫描(LORETA)的方法，对精神分裂症患者在奥尔兹治疗前后的P300电流源密度的解剖分布进行了研究。正常对照组受试者在颞区表现出P300电流密度的左侧优势偏侧，而精神分裂症受试者这一模式并不明显。用药6个月后，患者的P300电流密度恢复了左侧优势偏侧模式，并伴有言语学习记忆、生活质量和精神病理的改善。这项研究的结果首次证明，一些AAPD治疗精神分裂症记忆缺陷的能力可能与电生理活动解剖分布的变化有关。

项目成果

Effect of orthography on the verbal fluency performance in schizophrenia : Examination using Japanese patients.

正字法对精神分裂症患者语言流畅性的影响：使用日本患者进行的检查。

• 发表时间: 2004
• 期刊: Schizophr Res 69
• 作者: Sumiyoshi;C.;Sumiyoshi;T.;Matsui;M.;Nohara;S.;Yamashita;I.;Kurachi;M.
• 通讯作者: M.

The effect of hypertension and obesity on the development of diabetes mellitus in patients treated with atypical antipsychotic drugs.

高血压和肥胖对接受非典型抗精神病药物治疗的患者发生糖尿病的影响。

• 发表时间: 2004
• 期刊: Journal of Clinical Psychopharmacology 24
• 作者: Sumiyoshi et al.

Disorganization of semantic memory underlies alogia in schizophrenia: An analysis of verbal fluency performance in Japanese subjects

• DOI: 10.1016/j.schres.2004.05.011
• 发表时间: 2005-04-01
• 期刊: SCHIZOPHRENIA RESEARCH
• 影响因子: 4.5
• 作者: Sumiyoshi, C;Sumiyoshi, T;Niwa, S
• 通讯作者: Niwa, S

Verbal memory deficits in a preadolescent case of lesions of the left parahippocampal gyrus associated with a benign tumor.

与良性肿瘤相关的左侧海马旁回病变的青春期前病例的语言记忆缺陷。

• 发表时间: 2006
• 期刊: Prog. Neuropsychopharmacol. Biol. Psychiaty. 30
• 作者: Inoue;T;Nishimura;S;Havashi;N;Numagami;Y;Takazawa;H;Nishijima;M;Hasegawa S;Kurimoto M.;Nasser K.;Hayashi N.;Tsuboi Y.;Hayakawa Y.;Samii A.;Takeuchi M.;Inoue T.;Tsubota M.;Inoue T.;Jin D.;Hori F.;Hayashi N.;Li F.;Tada M.;Hibino Y.;Myint K. M.;Nomoto K.;Jin D.;Umemura K.;Sumiyoshi T.
• 通讯作者: Sumiyoshi T.

Verbal memory deficits in a preadolescent case of lesions of the left parahippocampal gyrus associated with a benign tumor

与良性肿瘤相关的左侧海马旁回病变的青春期前病例的语言记忆缺陷

• 发表时间: 2006
• 期刊: Prog. Neuropsychopharmacol. Biol. Psychiaty 30
• 作者: Sumiyoshi;T;Sumiyoshi;C;Nohara;S;Hagino;H;Hasegawa;S;Kuwayama;N;Endo;S;Kurachi;M
• 通讯作者: M