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Electrophysiology of the pulmonary vein in the left atrial volume-load model

左心房容量负荷模型中肺静脉的电生理学

基本信息

批准号：
16591418
负责人：
NITTA Takashi
金额：
$ 1.98万
依托单位：
Nippon Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591418/
关键词：
Atrial fibrillation Pulmonary vein Volume load Left atrium

项目摘要

Electrophysiology of the pulmonary veins in a left atrial volume-load model was studied. A shunt was made between the left subclavian artery and the left pulmonary artery in mongrel dogs. All the animals exhibited severe heart failure postoperatively. Some animals died of severe heart failure. The animals survived for 4 weeks were subjected to the pulmonary vein mapping study. Conduction velocity of the pulmonary veins was measured during pacing by means of custom-made a multi-electrode catheter. Data were compared with those obtained from the normal control animals. Diameter of each pulmonary vein was measured and myocardium sleeve extending into the pulmonary veins was examined microscopically.The conduction velocity decreased in the circumferential direction of the pulmonary veins in the volume-loaded animals. The change of the conduction velocity in the longitudinal direction varied and there was no significant difference between the control animals. Histological examination revealed that the myocardial sleeve was stretched and thinned in the circumferential direction. Fibrosis was also present. It remains uncertain whether the decrease in the conduction velocity was due to true decrease in the conduction velocity or increase of the caliber of the pulmonary vein.

在左心房容积负荷模型上研究了肺静脉的电生理。在杂种犬的左锁骨下动脉和左肺动脉之间进行分流。所有动物术后均出现严重心力衰竭。有些动物死于严重的心力衰竭。存活4周的动物进行肺静脉标测研究。通过定制的多电极导管测量起搏过程中肺静脉的传导速度。将数据与正常对照动物的数据进行比较。测量肺静脉内径，镜下观察肺静脉内心肌袖，发现肺静脉周向传导速度减慢。传导速度在纵向上的变化各不相同，对照组动物之间无显著差异。组织学检查显示心肌袖在圆周方向被拉伸变薄。还存在纤维化。目前尚不确定传导速度的降低是由于传导速度的真正降低还是肺静脉口径的增加。

项目成果

期刊论文数量（26）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

心臓外科(新井達太、編)

心脏外科（新井龙太编辑）

DOI：
发表时间：
2005
期刊：
影响因子：
0
作者：
Isomatsu Y;Shin'oka T;Aoki M;Terada M;Takeuchi T;Hoshino S;Takanashi Y;Imai Y;Kurosawa H;新田隆;Shin'oka T;新田隆
通讯作者：
新田隆

Surgery for atrial fibrillation.

DOI：
10.1016/j.ccl.2014.07.003
发表时间：
2014-11
期刊：
Cardiology clinics
影响因子：
2.4
作者：
Lawrance CP;Henn MC;Damiano RJ Jr
通讯作者：
Damiano RJ Jr

Manual of Surgical Treatment of atrial fibrillation (Ed : Dr Sie, Dr D'Ancona, Dr Bartolozzi, Dr Beukema, Dr Doty)

心房颤动手术治疗手册（编者：Dr Sie、Dr DAncona、Dr Bartolozzi、Dr Beukema、Dr Doty）

DOI：
发表时间：
期刊：
影响因子：
0
作者：
Isomatsu Y;Shin'oka T;Aoki M;Terada M;Takeuchi T;Hoshino S;Takanashi Y;Imai Y;Kurosawa H;新田隆;Shin'oka T;新田隆;Toshiharu Shin'oka;Nitta T
通讯作者：
Nitta T

Map-guided surgery for atrial fibrillation.

地图引导的心房颤动手术。