The effect of pulmonary isolation on the initiation and sustenance of atrial fibrillation induced in left atrial, volume-load model

肺隔离对左心房容量负荷模型中诱发的心房颤动的发生和维持的影响

• 批准号: 18591565
• 负责人: NITTA Takashi
• 金额: $ 2.45万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591565/
• 关键词: Atrial fibrillation; Pulmonary vein; Volume load; Left atrium; 左房容量負荷

Effect of pulmonary isolation on the initiation and sustenance of atrial fibrillation was studied in canine left atrial volume-load model. A shunt was made between the left subclavian artery and the left pulmonary artery in mongrel dogs. All the animals exhibited severe heart failure postoperatively. Some animals died of severe heart failure. Rapid pacing at the left atrial appendage was initiated one week after the shunt surgery. The animals survived for 4 weeks were subjected to the pulmonary vein mapping study.Continuous atrial fibrillation was observed in all animals. The cycle length of the left atrial electrograms was shorter than that of the right atrial electrograms. The cycle length progressively shortened during the 4 weeks. Atrial activation maps during atrial fibrillation showed repetitive activation originated from the right and left superior pulmonary veins and fibrillatory conduction to the right atrium. Pulmonary vein isolation was performed by means of bipolar radiofrequency ablation device. Atrial fibrillation was not terminated in any animals.In addition to the repetitive activation in the pulmonary veins, atrial reentrant activations or non-pulmonary vein abnormal activations might have played a role in the sustenance of atrial fibrillation in the left atrial volume-load model.

在犬左心房容积负荷模型上研究了肺隔离对心房颤动发生和维持的影响。在杂种犬的左锁骨下动脉和左肺动脉之间进行分流。所有动物术后均出现严重心力衰竭。有些动物死于严重的心力衰竭。分流术后1周开始左心耳快速起搏。存活4周的动物进行肺静脉标测，所有动物均观察到持续性房颤。左房电图的周期长度短于右房电图。在4周内，周期长度逐渐缩短。心房颤动时心房激动标测图显示源自左右上级肺静脉的重复激动和向右心房的传导。采用双极射频消融装置进行肺静脉电隔离。任何动物的房颤都没有终止。除了肺静脉的重复激动外，心房折返激动或非肺静脉异常激动可能在左心房容量负荷模型中对房颤的维持发挥了作用。

项目成果

Map-guided Surgical Ablation

地图引导手术消融

• 发表时间: 2008
• 作者: 村田智幸;藤本哲男;他;Nitta T.
• 通讯作者: Nitta T.

The Mechanisms and Radiofrequency Catheter Ablation of Atrial Tachycardia Following Surgery for Atrial Fibrillation.

房颤手术后房性心动过速的机制和射频导管消融。

• 发表时间: 2006
• 作者: Miyauchi;Y.;Kobayashi;Y.;Nitta;T.;Maruyama;M.;Iwasaki;Y.;Horie;T.;Taniguchi;H.;Ueno;A.;Tateoka;K.;Okazaki;R.;Hayashi;M.;Ishii;Y.;Katoh;T.;Takano;T
• 通讯作者: T

Surgery for atrial fibrillation.

• DOI: 10.1016/j.ccl.2014.07.003
• 发表时间: 2014-11
• 期刊: Cardiology clinics
• 影响因子: 2.4
• 作者: Lawrance CP;Henn MC;Damiano RJ Jr
• 通讯作者: Damiano RJ Jr

Histopathological evaluation of left atrial appendage thrombogenesis removed during surgery for atrial fibrillation

房颤手术中切除左心耳血栓形成的组织病理学评估

• 发表时间: 2007
• 期刊: Am Heart J 153
• 作者: Saito T;et. al.
• 通讯作者: et. al.

Electroanatomical mapping-guided implantation of atrial pacemaker leads in idiopathic atrialfibrosis presenting partial atrial standstill and complete atrioventricular block : Improvement of left atrial contractility by achievement of A-V synchrony

电解剖标测引导心房起搏器植入导致特发性心房纤维化，表现为部分心房停顿和完全房室传导阻滞：通过实现 A-V 同步改善左心房收缩力

• 发表时间: 2007
• 作者: Miyauchi;Y.;Kobayashi;Y.;Maruyama;M.;Iwasaki;Y.;Hirasawa;Y.;Ueno;A.;Okazaki;R.;Murata;H.;Ohara;T.;Nitta;T.;Katoh;T.;Takano;T
• 通讯作者: T