The effect of pulmonary isolation on the initiation and sustenance of atrial fibrillation induced in left atrial, volume-load model

肺隔离对左心房容量负荷模型中诱发的心房颤动的发生和维持的影响

• 批准号: 18591565
• 负责人: NITTA Takashi
• 金额: $ 2.45万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591565/
• 关键词: Atrial fibrillation; Pulmonary vein; Volume load; Left atrium; 左房容量負荷

Effect of pulmonary isolation on the initiation and sustenance of atrial fibrillation was studied in canine left atrial volume-load model. A shunt was made between the left subclavian artery and the left pulmonary artery in mongrel dogs. All the animals exhibited severe heart failure postoperatively. Some animals died of severe heart failure. Rapid pacing at the left atrial appendage was initiated one week after the shunt surgery. The animals survived for 4 weeks were subjected to the pulmonary vein mapping study.Continuous atrial fibrillation was observed in all animals. The cycle length of the left atrial electrograms was shorter than that of the right atrial electrograms. The cycle length progressively shortened during the 4 weeks. Atrial activation maps during atrial fibrillation showed repetitive activation originated from the right and left superior pulmonary veins and fibrillatory conduction to the right atrium. Pulmonary vein isolation was performed by means of bipolar radiofrequency ablation device. Atrial fibrillation was not terminated in any animals.In addition to the repetitive activation in the pulmonary veins, atrial reentrant activations or non-pulmonary vein abnormal activations might have played a role in the sustenance of atrial fibrillation in the left atrial volume-load model.

在犬左心房体积载荷模型中研究了肺部隔离对心房颤动的起始和维持的影响。在杂种狗的左锁骨下动脉和左肺动脉之间进行了分流。所有动物术后均表现出严重的心力衰竭。一些动物死于严重的心力衰竭。分流手术后一周开始，左心脏附属物的快速起搏开始。对所有动物进行了肺静脉图研究研究。左心电图的循环长度比右心房电图的循环长度短。周期长度在4周内逐渐缩短。心房颤动期间的心房激活图显示重复激活起源于左右肺静脉，并向右心房传导纤颤传导。通过双极射频消融装置进行肺静脉分离。在任何动物中均未终止心房颤动。除了肺静脉的重复激活，心房再入侵活化或非肺静脉异常激活可能在左心室体积载荷模型中的心房纤维化中起作用。

项目成果

The Mechanisms and Radiofrequency Catheter Ablation of Atrial Tachycardia Following Surgery for Atrial Fibrillation.

房颤手术后房性心动过速的机制和射频导管消融。

• 发表时间: 2006
• 作者: Miyauchi;Y.;Kobayashi;Y.;Nitta;T.;Maruyama;M.;Iwasaki;Y.;Horie;T.;Taniguchi;H.;Ueno;A.;Tateoka;K.;Okazaki;R.;Hayashi;M.;Ishii;Y.;Katoh;T.;Takano;T
• 通讯作者: T

Map-guided Surgical Ablation

地图引导手术消融

• 发表时间: 2008
• 作者: 村田智幸;藤本哲男;他;Nitta T.
• 通讯作者: Nitta T.

Surgery for Atrial Fibrillation

• DOI: 10.1016/b978-0-323-46294-5.00028-5
• 发表时间: 2018-11
• 期刊: Atlas of Cardiac Surgical Techniques
• 作者: Jason O. Robertson;Lindsey L. Saint;Ralph J. Damiano

Use of Bipolar Radiofrequency Ablation Devices Does Not Under mine the Efficacy of Surgery for AF

使用双极射频消融装置不会降低房颤手术的疗效

• 发表时间: 2007
• 作者: Ishu Y;et. al.
• 通讯作者: et. al.

Manual of Surgical Treatment of atrial fibrillation(Editors:D'Ancona G, Sie H, Bartolozzi F, Beukema W, Doty D)

房颤手术治疗手册（编者：DAncona G、Sie H、Bartolozzi F、Beukema W、Doty D）

• 发表时间: 2008
• 作者: 坂田亮;藤本哲男;他;Nitta T
• 通讯作者: Nitta T