The prophylactic effect of pulmonary vein isolation on the occurrence of atrial fibrillation in a left atrial volume load canine model

为了测试预防性肺静脉隔离是否防止房颤的发展，在锁骨下动脉-肺动脉犬模型中通过双极射频消融装置进行左心房窦环形消融。左心房内径逐渐增大。心房激动周期逐渐缩短，尤其是在左心房。在房颤期间，在上级肺静脉观察到局灶性快速激动。这些激活被肺静脉隔离阻断。

To test if prophylactic pulmonary vein isolation prevents development of atrial fibrillation, the left atrial antrum circular ablation was performed by a bipolar radiofrequency ablation device in a subclavian artery - pulmonary artery canine model. The left atrial dimension was progressively increased. The atrial activation cycles were progressively shortened, particularly in the left atrium. During atrial fibrillation, focal rapid activations were observed at the superior pulmonary veins. These activations were blocked by the pulmonary vein isolation.