Clinical basic research for the surgical treatment of the cervical carotid artery stenosis.

颈动脉狭窄手术治疗的临床基础研究。

• 批准号: 16591433
• 负责人: ENDO Shunro
• 金额: $ 2.18万
• 依托单位: TOYAMA UNIVERSITY (2005)Toyama Medical and Pharmaceutical University (2004)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591433/
• 关键词: atheroma-thrombus; carotid artery stenosis; carotid artery occlusion; plateletaggregation; heparincofactor II; clamidia pneumonia; heparin; 脳高次機能; 頸動脈分岐部; 均整動脈; 石灰化; 内膜切除術; ステント留置術; 頚動脈分岐部

The purpose of this study is to approach clinical-pathological feature of the carotid artery stenosis, ; especially about the arterial wall characteristics, and pathological meaning of heparin cofactor II and platelet aagregation,.During 2 year research periods, the following four subjects were revealed as new evidence in this field, and important topics were reported in the journal.1 Characteristic pathological findings of the arterial wall changes at the carotid bifurcation : relationship of the changes the elastic/muscular artery and limitation of the atheroma plaque extention.These findings should reveal important information for surgical and endovascular treatment strategy.2 Physiological and pathological mechanisms of heparin cofactor II.3 Monitoring of platelet aggregation and heparin activation in patients undergoing neuroendovascular treatment or angiography.Based on these studies, we continued research to investigate true pathological features of the carotid artery disease and to create the most adequate treatment selection and methods.

这项研究的目的是处理颈动脉狭窄的临床病理特征； especially about the arterial wall characteristics, and pathological meaning of heparin cofactor II and platelet aagregation,.During 2 year research periods, the following four subjects were revealed as new evidence in this field, and important topics were reported in the journal.1 Characteristic pathological findings of the arterial wall changes at the carotid bifurcation : relationship of the changes the elastic/muscular artery and limitation of the atheroma plaque extention.These findings should reveal important information for surgical and endovascular treatment strategy.2 Physiological and pathological mechanisms of heparin cofactor II.3 Monitoring of platelet aggregation and heparin activation in patients undergoing neuroendovascular treatment or angiography.Based on these studies, we continued research to investigate true pathological features of the carotid artery disease and to create the most adequate treatment selection and methods.

项目成果

頸部内頸動脈狭窄-CEAかステントか-

颈椎颈内动脉狭窄-CEA还是支架？

• 发表时间: 2005
• 期刊: 脳と神経 67
• 作者: 遠藤俊郎;他
• 通讯作者: 他

脳外科手術適応と脳循環-内頚動脈剥離術-

神经外科适应症和脑循环 - 颈内动脉夹层 -

• 发表时间: 2004
• 期刊: CLINICAL SCIENCE 22(4)
• 作者: 久保道也;遠藤俊郎
• 通讯作者: 遠藤俊郎

頸部内頸動脈狭窄症

颈部颈内动脉狭窄

• 发表时间: 2005
• 期刊: 脳と神経 57・7
• 作者: 清水弘之;川合謙介;須永茂樹;山田俊隆;遠藤俊郎ほか
• 通讯作者: 遠藤俊郎ほか

Surgical anatomy of the cervical carotid artery for carotid endarterectomy

• DOI: 10.2176/nmc.45.25
• 发表时间: 2005-01-01
• 期刊: NEUROLOGIA MEDICO-CHIRURGICA
• 影响因子: 1.9
• 作者: Hayashi, N;Hori, E;Endo, S
• 通讯作者: Endo, S

Adenovirus-mediated expression of heparin cofactor II inhibits thrombin-induced cellular esponses in fibroblasts and vascular smooth muscle cells.

腺病毒介导的肝素辅因子 II 表达可抑制成纤维细胞和血管平滑肌细胞中凝血酶诱导的细胞反应。

• 发表时间: 2005
• 期刊: Thrombosis Research 116
• 作者: Hayakawa Y;Endo S et al.
• 通讯作者: Endo S et al.