Clinicopathological study of the pathogesis of the advanced atherosclerotic occlusive lesions of carotid artery.

颈动脉晚期动脉粥样硬化闭塞性病变发病机制的临床病理学研究。

• 批准号: 04670853
• 负责人: ENDO Shunro
• 金额: $ 1.34万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670853/
• 关键词: carotid artery; atherosclerosis; stenosis; occlusion; pathogenesis; plaque hemorrhage; thrombus; vasa vasorum; plaque hemorrhage; Thrombus; Carotid Artery; Aterosclerosis; Stenosis; Occlusion; Pathogenesis; Plaque Hemorrhage; Vasa Vasorum

In this study, pathogenesis of an advanced atherosclerotic occlusive lesion of the carotid artery.Summary of the results are as follows and part of them has been presented in a couple of papers.1) Clincopathological study, based on the specimens which were obtained from nearly or completely occluded lesions and by emergency endarterectomy, suggested that intraplaque hemorrhage is the most important pathogenetic factor of the advanced atheroscleotic lesions. It is also revealed that rupture of the developted vasavasorum should be cause of these intraplaque hemorrhage.2) In experimental study, preparation of animal model with advanced atherosclerotic occlusive lesions has been continued. In conclusion, sufficient model could not be produced in the past three years, although transient pathological changes were obtained.3) In addition to the cervical carotid arteries, development of intra-arterial wall hemorrhage and vasa vasorum were revieled in the intracranial arteries. Significance of these findings to the pathogenesis of intracranial dissecting aneurysm has benn also investigated.

在这项研究中，颈动脉的先进动脉粥样硬化闭塞性病变的发病机制如下。在几篇论文中，其中的一部分已在几篇论文中呈现。1）基于几乎或几乎完全是完全粘附的病变的crincoparologicy研究。动脉粥样硬化病变。还揭示了开发的vasavasorum的破裂应该是这些腔内出血的原因。2）在实验研究中，在进行先进的动脉粥样硬化性闭塞性病变的动物模型的制备过程中继续进行。总之，在过去三年中无法产生足够的模型，尽管还获得了短暂的病理变化。3）除了颈颈动脉，在颅内动脉中还兴奋了颈颈动脉，动脉内壁出血和瓦萨·纳索姆。这些发现对颅内解剖动脉瘤的发病机理的重要性也研究了。

项目成果

Endo S,Takaku A,et al: "A pathological study of intracranial posterior circulation dissecting aneurysm with subarachnoid hemorrhage." Neurosurgery. 33. 732-738 (1993)

Endo S、Takaku A 等人：“颅内后循环夹层动脉瘤伴蛛网膜下腔出血的病理学研究”。

Endo S,Takaku A,et al.: "A pathological study of intracranial posterior circulation dissecting aneurysm with subarachnoid hemorrhage." Neurosurgery. 33. 732-738 (1993)

Endo S、Takaku A 等人：“颅内后循环夹层动脉瘤伴蛛网膜下腔出血的病理学研究”。

遠藤俊郎 他: "頸動脈血栓内膜切除術の手術手技と適応" Neurosurgcons. 13. 118-124 (1994)

Toshiro Endo 等人：“颈动脉内膜切除术的手术技术和适应症”Neurosurgcons。13. 118-124 (1994)。

Endo S,Furuichi S,et al: "Clinical study of enlarged infundibular dilatation of the posterior communicating artery." J Neurosurg. to be published.

Endo S，Furuichi S，et al：“后交通动脉漏斗部扩张扩大的临床研究。”

遠藤俊郎 他: "頸動脈血栓内壁切除術の手術手段と適応" Neurosurgeons. 13. 118-124 (1994)

Toshiro Endo 等人：“颈动脉血栓切除术的手术方法和适应症”《神经外科医生》13. 118-124 (1994)。