Clarification of new brain peptide's pathophysiologic role and molecular mechanism in arthritic animal model.

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Galanin-like peptide (GALP) was found from searching for orphan receptor ligands. GALP is exists in the hypothalamic arcuate nucleus, however, there is no knowledge about its relationship between GALP and chronic arthritis. On the basis of these circumstances, the purpose of this study was to investigate influence of GALP for chronic stress particularly in experimental arthritis. Practically, we evaluated GALP gene expression not only in acute stress stimulation (osmotic challenge and LPS injection), but also in chronic inflammatory stress stimulation (adjuvant arthritis). In result, we clarified following facts. GALP gene expression at the arcuate nucleus neuron was dependent on leptin and regulated by blood sugar control caused by insulin administration. Osmotic challenge has a potent stimulation for influence in GALP gene expression at posterior pituitary cells. Increase of the GALP gene expression in chronic inflammatory stress was possibly regulated by prostaglandin system. Long before, various change of central nervous system based on chronic inflammatory stress in patients with rheumatoid arthritis has been reported in addition to typical joint deformity and inflammatory change. Almost various mechanisms in physiological reaction are still unknown. However, we have to evaluate furthermore about the influence of central nervous system especially hypothalamus in pathogenesis of rheumatoid arthritis which is peripheral chronic inflammatory disease.