Molecular basis clarification for pain and stress reaction in injury and arthritis of transgenic animals.

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The purpose of the study was to examine the relationship between acceptance of nociceptive stress at peripheral tissue and response against the stress at the central nervous system. We obtained significant results as follow. (1) Formalin test which was acute nociceptive stress model induced rapid neuroendocrine response in the hypothalamus. (2) Immediate early gene expression which was widely used for indication of activated of neurons was observed in the dorsal horn of the spinal cord and the hypothalamic paraventricular nucleus after nociceptive stress. (3) Receptor-activated Ca2+-channels such as transient receptor potential involved in processing nociceptive stress in the peripheral tissue.