Critical illness myopathy and timely electrical muscle stimulation

危重症肌病及时进行肌肉电刺激

• 批准号: 47182602
• 负责人: Professor Dr. Steffen Weber-Carstens
• 金额: --
• 依托单位: Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/47182602?language=en
• 关键词: Critical; illness; myopathy; timely; electrical

We are studying critical illness myopathy (CIM), a devastating wasting disease of ICU patients that leads to nerve and muscle degeneration. Muscle membrane inexcitability and myosin loss in typ IIa and IIb fast twitch muscle fibers occurs within a week of ICU admission, a time interval where assessment and treatment directed at CIM are almost impossible. We recently found that electrical muscle stimulation (EMS) at onset of CIM could be of utility in terms of prevention and treatment. We now aim to investigate the impact of EMS during early CIM on neuromuscular function, muscle membrane excitability, structural changes of muscle composition (thick filament loss), and regulation of atrophy gene expression (MURF-I and Atrogin), in a prospective randomized trial. Since others and we observed early metabolic changes involving carbohydrate metabolism in early CIM, we will also investigate the impact of EMS on insulin sensitivity, insulin signaling, and muscle metabolism during early critical illness.

我们正在研究危重疾病肌病(CIM)，这是ICU患者的一种毁灭性的消耗性疾病，会导致神经和肌肉退化。IIa型和IIb型快速抽动肌纤维的肌膜不兴奋性和肌球蛋白丢失发生在ICU入院的一周内，这段时间几乎不可能针对CIM进行评估和治疗。我们最近发现，在CIM开始时进行电肌肉刺激(EMS)在预防和治疗方面可能是有用的。我们现在的目标是在一项前瞻性的随机试验中，研究早期CIM期间EMS对神经肌肉功能、肌膜兴奋性、肌肉成分的结构变化(粗丝丢失)以及萎缩基因表达的调节(MURF-I和Atrogin)的影响。由于其他人和我们在早期CIM中观察到了涉及碳水化合物代谢的早期代谢变化，我们也将研究EMS在早期危重疾病中对胰岛素敏感性、胰岛素信号转导和肌肉代谢的影响。