Animal model development and research for understanding the pathogenesis of hypertrophic scar and development of therapeutic agent

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Hypertrophic scaring is a devastating problem after trauma and surgery. Mary researches have been extensively achieved, but the pathophysiology is still unknown and no therapeutic agent breakthrough. One of this reason is the lack of good animal model for hypertrophic scaring. Female Red Droc Pig(FRDP) is a novel animal model but the pig become very big and body weight becomes over 200Kg and handling of the pig is very difficult and need large space for experiments.The clawn miniature swine which we used, is much easier to use in the study and confirmed that it's scar is fully compatible to human hypertrophic scar.Using this model, we found that the tissue chymase activity was deeply related to the thickness of the hypertrophic scar. We speculate that chymase participate in the pathophysiology of hypertrophic scar and anti-chymase agents is potentially effective therapeutic agent for hypertrophic scarring.