Surface modification of titanium implant to control arrangement of attachment cells

钛植入物的表面修饰以控制附着细胞的排列

• 批准号: 16591951
• 负责人: ABE Yasuhiko
• 金额: $ 2.3万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591951/
• 关键词: Implant; Pure titanium; Surface modification; Phospho-amino acid; Phospho-peptide; Osteoblast; Cell adhesion molecules; 細胞接着分子

The purpose of this study was to investigate a new biochemical surface modification technique for titanium implants using phospho-amino acids (o-phospho-L-serine, o-phospho-L-threonine) and phospho-peptides (RGDS(PO_3H_2)PA peptide, RGDXXXXXS(PO_3H_2)PA (X=MiniPEG) peptide) to control arrangement of attachment cells. X-ray photoelectron spectroscopy (XPS) and surface plasmon resonance (SPR) chemically analyzed the modified surface. It is concluded that the phospho-amino acids and the phospho-peptides chemically bonded to the titanium surface treated with HCl. These findings indicate the possibility of a new biochemical modification of titanium implant to induce specific cell and tissue responses by means of the surface immobilized with peptides, proteins, or growth factors.

本研究的目的是探索一种新的生物化学表面改性技术，利用磷酸化氨基酸（o-磷酸-L-丝氨酸，o-磷酸-L-苏氨酸）和磷酸化肽（RGDS（PO_3H_2）PA肽，RGDXXXXXS（PO_3H_2）PA（X=MiniPEG）肽）来控制附着细胞的排列。X射线光电子能谱（XPS）和表面等离子体共振（SPR）化学分析的改性表面。结果表明，磷酸化氨基酸和磷酸化肽以化学键的形式结合在经盐酸处理的钛表面上。这些研究结果表明，一种新的生物化学修饰的钛植入物诱导特定的细胞和组织的反应，通过与肽，蛋白质，或生长因子的表面固定的装置的可能性。

项目成果

New surface modification of titanium implant with phospho-amino acid

• DOI: 10.4012/dmj.24.536
• 发表时间: 2005-12-01
• 期刊: DENTAL MATERIALS JOURNAL
• 影响因子: 2.5
• 作者: Abe, Y;Hiasa, K;Akagawa, Y
• 通讯作者: Akagawa, Y