Surface modification of titanium implant to control arrangement of attachment cells

本研究旨在探讨利用磷酸氨基酸（o-磷酸- l -丝氨酸、o-磷酸- l -苏氨酸）和磷酸肽(RGDS(PO_3H_2)PA肽、RGDXXXXXS（PO_3H_2)PA （X=MiniPEG）肽）控制钛植入体附着细胞排列的生化表面修饰新技术。x射线光电子能谱（XPS）和表面等离子体共振（SPR）对改性后的表面进行了化学分析。结果表明，在HCl的作用下，钛表面的磷酸氨基酸和磷酸肽发生了化学键合。这些发现提示了一种新的生物化学修饰钛植入物的可能性，通过肽、蛋白质或生长因子的表面固定来诱导特定的细胞和组织反应。

The purpose of this study was to investigate a new biochemical surface modification technique for titanium implants using phospho-amino acids (o-phospho-L-serine, o-phospho-L-threonine) and phospho-peptides (RGDS(PO_3H_2)PA peptide, RGDXXXXXS(PO_3H_2)PA (X=MiniPEG) peptide) to control arrangement of attachment cells. X-ray photoelectron spectroscopy (XPS) and surface plasmon resonance (SPR) chemically analyzed the modified surface. It is concluded that the phospho-amino acids and the phospho-peptides chemically bonded to the titanium surface treated with HCl. These findings indicate the possibility of a new biochemical modification of titanium implant to induce specific cell and tissue responses by means of the surface immobilized with peptides, proteins, or growth factors.