Surface modification of titanium implant to control arrangement of attachment cells

本研究的目的是探索一种新的生物化学表面改性技术，利用磷酸化氨基酸（o-磷酸-L-丝氨酸，o-磷酸-L-苏氨酸）和磷酸化肽（RGDS（PO_3H_2）PA肽，RGDXXXXXS（PO_3H_2）PA（X = MiniPEG）肽）来控制附着细胞的排列。X射线光电子能谱（XPS）和表面等离子体共振（SPR）化学分析的改性表面。结果表明，磷酸化氨基酸和磷酸化肽以化学键的形式结合在经盐酸处理的钛表面上。这些研究结果表明，一种新的生物化学修饰的钛植入物诱导特定的细胞和组织的反应，通过表面固定肽，蛋白质，或生长因子的可能性。

The purpose of this study was to investigate a new biochemical surface modification technique for titanium implants using phospho-amino acids (o-phospho-L-serine, o-phospho-L-threonine) and phospho-peptides (RGDS(PO_3H_2)PA peptide, RGDXXXXXS(PO_3H_2)PA (X=MiniPEG) peptide) to control arrangement of attachment cells. X-ray photoelectron spectroscopy (XPS) and surface plasmon resonance (SPR) chemically analyzed the modified surface. It is concluded that the phospho-amino acids and the phospho-peptides chemically bonded to the titanium surface treated with HCl. These findings indicate the possibility of a new biochemical modification of titanium implant to induce specific cell and tissue responses by means of the surface immobilized with peptides, proteins, or growth factors.