Collaborative Research: Understanding Machining-Induced Influences to Ultra-Fine Grained Pure Titanium for Biomedical Applications

该合作研究奖支持用于生物医学应用的超细晶粒纯钛加工的基础研究。该研究将测试这样一个假设，即机械加工会导致严重塑性变形加工的超细晶粒金属的微观结构变化，这会影响它们的功能和细胞-材料相互作用性能。具体而言，主要研究活动包括使用等通道角挤压制造块体超细晶钛，表征加工引起的微观结构变化和功能变化的晶粒尺寸，位错密度，残余应力和腐蚀行为，并调查加工引起的细胞-材料相互作用的变化在成骨细胞粘附和增殖方面。由于钛在医疗植入物和修复体中的应用前景，因此将对超细晶钛棒进行研究，研究结果将为严重塑性变形加工的大块超细晶钛的机械加工引起的材料性能变化和功能改变提供知识和理解。该方法将有助于在需要高强度和耐腐蚀性的医疗保健行业以及需要高强度重量比的汽车行业中采用超细晶粒金属。这个合作研究项目的特点是材料加工，机械加工和生物医学制造研究人员之间的独特合作。研究活动将促进医疗保健应用的先进制造，以及通过课程开发进行材料，材料加工和制造的学科教育。这项研究也将积极影响不同群体的参与和促进科学，技术，工程和数学活动在佛罗里达，得克萨斯州A M大学和格鲁吉亚理工大学。

This collaborative research award supports fundamental research on machining of ultra-fine grained pure titanium for biomedical applications. The research will test the hypothesis that machining induces microstructure changes in severe plastic deformation-processed ultra-fine grained metals, which affects their functionality and cell-material interaction performance. Specifically, key research activities include fabricating bulk ultra-fine grained titanium using equal channel angular extrusion, characterizing the machining-induced microstructure change and functionality variation in terms of grain size, dislocation density, residual stress, and corrosion behavior, and investigating machining-induced cell-material interaction alterations in terms of osteoblast cell adhesion and proliferation. Ultra-fine grained titanium bars will be studied because of titanium's promising use for medical implants and prosthetics.Research results will provide knowledge and understanding of machining-induced material property variations and functionality alterations of severe plastic deformation-processed bulk ultra-fine grained titanium. The methodology will contribute to the adoption of ultra-fine grained metals in the healthcare industry requiring high strength and corrosion resistance and the automobile industry requiring high strength-to-weight ratios. This collaborative research project features a unique collaboration among materials processing, machining, and biomedical manufacturing researchers. The research activities will promote advanced manufacturing for healthcare applications as well as disciplinary education in materials, materials processing, and manufacturing through curriculum development. The research will also positively impact the participation of diverse groups and promotion of Science, Technology, Engineering, and Mathematics activities at the University of Florida, Texas A&M, and Georgia Tech.