Collaborative Research: Understanding Machining-Induced Influences to Ultra-Fine Grained Pure Titanium for Biomedical Applications

该合作研究奖支持用于生物医学应用的超细晶粒纯钛加工的基础研究。该研究将验证机械加工诱导超细晶金属剧烈塑性变形的微观结构变化，从而影响其功能和细胞-材料相互作用性能的假设。具体而言，重点研究活动包括使用等通道角挤压法制备大块超细晶钛，表征加工诱导的微观结构变化和晶粒尺寸、位错密度、残余应力和腐蚀行为方面的功能变化，以及研究加工诱导的细胞-材料相互作用在成骨细胞粘附和增殖方面的变化。由于钛在医疗植入物和假肢方面的应用前景广阔，超细颗粒钛棒将被研究。研究结果将提供知识和理解加工引起的材料性能变化和功能变化的严重塑性变形处理的大块超细晶粒钛。该方法将有助于在需要高强度和耐腐蚀性的医疗保健行业和需要高强度重量比的汽车行业采用超细颗粒金属。这个合作研究项目的特点是材料加工、机械加工和生物医学制造研究人员之间的独特合作。研究活动将通过课程开发促进医疗保健应用的先进制造以及材料，材料加工和制造方面的学科教育。这项研究还将对佛罗里达大学、德克萨斯a&m大学和佐治亚理工学院的各种团体的参与和科学、技术、工程和数学活动的促进产生积极影响。

This collaborative research award supports fundamental research on machining of ultra-fine grained pure titanium for biomedical applications. The research will test the hypothesis that machining induces microstructure changes in severe plastic deformation-processed ultra-fine grained metals, which affects their functionality and cell-material interaction performance. Specifically, key research activities include fabricating bulk ultra-fine grained titanium using equal channel angular extrusion, characterizing the machining-induced microstructure change and functionality variation in terms of grain size, dislocation density, residual stress, and corrosion behavior, and investigating machining-induced cell-material interaction alterations in terms of osteoblast cell adhesion and proliferation. Ultra-fine grained titanium bars will be studied because of titanium's promising use for medical implants and prosthetics.Research results will provide knowledge and understanding of machining-induced material property variations and functionality alterations of severe plastic deformation-processed bulk ultra-fine grained titanium. The methodology will contribute to the adoption of ultra-fine grained metals in the healthcare industry requiring high strength and corrosion resistance and the automobile industry requiring high strength-to-weight ratios. This collaborative research project features a unique collaboration among materials processing, machining, and biomedical manufacturing researchers. The research activities will promote advanced manufacturing for healthcare applications as well as disciplinary education in materials, materials processing, and manufacturing through curriculum development. The research will also positively impact the participation of diverse groups and promotion of Science, Technology, Engineering, and Mathematics activities at the University of Florida, Texas A&M, and Georgia Tech.