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Development of titanium alloy for implant with high corrosion resistance and prompt bone connectivity

开发具有高耐腐蚀性和快速骨连接的植入物钛合金

基本信息

批准号：
16591956
负责人：
NAKAGAWA Masaharu
金额：
$ 2.3万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591956/
关键词：
Titanium Titanium Alloy Bioactivity Surface Modification Hydro-thermal Treatment Implant Bone Contact Ratio Bone Connective 細胞培養

项目摘要

Because titanium has an excellent corrosion resistance and a biocompatibility, it is used for an artificial hip joint and a dental implant, etc. as a metallic material for the living body. The compatibility of titanium with the bone is more excellent than that of other materials. However, there is a case removed after implantation by the micro movement etc. The aim of this research is a development of surface modification method for the titanium implant to give a strong and prompt bone.There is a method of calling the alkali treatment to make one of the expected surface modification method extract a bone-like apatite layer directly to the surface of titanium. The material is soaked in a simulated body fluid, and the bioactivity of titanium is appreciable according to whether apatite precipitate on it.In this study, in order to fix a small amount of Ca to the surface of titanium beforehand, a hydro-thermal treatment was given at 200C by using 10mmol/L CaCl_2 solution paying attention to the generation mechanism of apatite in vivo. Pure Ti and the Ti alloy with this treatment showed that an initial attachment and a proliferation speed of the osteoblast cell gathered from rat's bone marrow were higher than those with the alkali treatment.The titanium implant with this treatment was implanted in rat's tibia bone and interface of bone and implant was observed. After implantation for 1 week, the bone contact rate of the titanium with this treatment indicated the more than 55% while the titanium with non-treatment indicated 5.7%. And that value reached about 100% after implantation for 4 weeks.From the above-mentioned result, it was suggested that the hydro-thermal treatment that used the CaCl_2 solution was a surface modification method giving bioactivity for titanium.

由于钛具有优异的耐腐蚀性和生物相容性，因此其作为用于生物体的金属材料用于人工髋关节和牙科植入物等。钛与骨的相容性优于其他材料。然而，有一种情况下，通过植入后的微运动等删除。本研究的目的是为钛植入物的表面改性方法的发展，给一个强大的和迅速的骨。有一种方法，叫碱处理，使一个预期的表面改性方法之一提取骨样磷灰石层直接到钛表面。本研究采用10 mmol/LCaCl_2溶液在200 ℃下对钛表面进行水热处理，以预先将少量的Ca固定在钛表面上，并注意到磷灰石在体内的生成机制。纯钛和经碱处理的钛合金，从大鼠骨髓中采集的成骨细胞的初始附着和增殖速度均高于碱处理的成骨细胞，将经碱处理的钛合金植入大鼠胫骨中，观察骨与种植体的界面。植入1周后，经处理的钛的骨接触率超过55%，而未经处理的钛的骨接触率为5.7%。上述结果表明，采用CaCl_2溶液的水热处理是一种赋予钛生物活性的表面改性方法。