Development of implant surface modification method for rapid osteoconductivity and gingival epithelial adhesiveness

开发快速骨传导性和牙龈上皮粘附性的种植体表面修饰方法

• 批准号: 20592301
• 负责人: NAKAGAWA Masaharu
• 金额: $ 3万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592301/
• 关键词: チタン; インプラント; 上皮歯肉付着性; 骨結合性; 表面改質処理; 歯肉上皮細胞(GE1); 骨結合強度

Initial cell attachment and cell proliferation were examined by using gingival epithelial cell (GE1) of mouse origin to examine adhesiveness of epithelial cell of implant in gingival penetration part. As for the titanium treated by hydrothermally in calcium chloride solution, the result of initial attachment of GE1 cell was significantly high compared with untreated titanium. As for the cell proliferation, a significant difference was not admitted though the untreated titanium indicated some high values. Therefore, it was suggested that the hydrothermal treatment with CaCl2 was able to improve the gingiva adhesiveness in the gingiva penetration part of the titanium implant.

用小鼠牙龈上皮细胞(GE1)检测种植体上皮细胞在牙周穿透部的黏附情况。在氯化钙溶液中水热处理的钛，其GE1细胞的初始贴壁率显著高于未处理的钛。在细胞增殖方面，虽然未处理的钛显示出一些较高的值，但差异不显著。因此，CaCl2水热处理能够改善钛种植体牙周穿透部的牙周粘附性。

项目成果

Effect of CaCl2 hydrothermal treatment on the bone bond strength and osteoconductivity of Ti-0.5Pt and Ti-6Al-4V-0.5Pt alloy

CaCl2水热处理对Ti-0.5Pt和Ti-6Al-4V-0.5Pt合金骨结合强度和骨传导性的影响

• 发表时间: 2009
• 期刊: Journal of Materials Science : Materials in Medicine 20
• 作者: M.Nakagawa;J.Yamazoe
• 通讯作者: J.Yamazoe

Effect of CaCl2 hydrothermal treatment on the bone bond strength and osteoconductivity of Ti–0.5Pt and Ti–6Al–4V–0.5Pt alloy implants

CaCl2水热处理对Ti-0.5Pt和Ti-6Al-4V-0.5Pt合金种植体骨结合强度和骨传导性的影响

• DOI: 10.1007/s10856-009-3799-9
• 发表时间: 2009
• 期刊: Journal of Materials Science: Materials in Medicine
• 作者: M. Nakagawa;Jyunichi Yamazoe
• 通讯作者: Jyunichi Yamazoe

Fibroblasts Attachment to CaCl2 Hydrothermally Treated Titanium Implant

成纤维细胞附着在 CaCl2 水热处理的钛植入物上

• 发表时间: 2011
• 作者: W.ELSHAHAWY;I.WATANABE;M.NAKAGAWA;P.R.KRAMER
• 通讯作者: P.R.KRAMER

Studies on Improving Osteoconductivity of Titanium by Hydrothermal Treatment

水热处理提高钛骨导性的研究

• 发表时间: 2009
• 作者: L.Zhang;M.Nakagawa;他
• 通讯作者: 他

Effect of molding pressure on fabrication of low-crystalline calcite block

• DOI: 10.1007/s10856-006-0028-7
• 发表时间: 2008-02-01
• 期刊: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
• 影响因子: 3.7
• 作者: Lin, Xin;Matsuya, Shigeki;Ishikawa, Kunio
• 通讯作者: Ishikawa, Kunio