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Development of surface modification method of titanium implant for rapid bone-bonding

快速骨结合钛种植体表面改性方法的开发

基本信息

批准号：
18592131
负责人：
NAKAGAWA Masaharu
金额：
$ 2.46万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

The authors found that the titanium oxide film which contained small amount Ca in the implant surface was formed by hydrothermal-treating a titanium implant with 10-20mmol/L calcium chloride aqueous solution at 200℃ and then that the generation of the bone-like apatite and initial attachment and proliferation of osteoblast cells were promoted. Moreover, the titanium implant which hydrothermal-treated in the calcium chloride aqueous solution of 10-20mmol/L was implanted in the tibia of the rat, and the connection condition of the implant and the bone was examined.It was shown that the bone-contact ratio was 55% (to be non-treated was 5.7%), 86% (to be non-treated was 19.2%), and 96% (to be non-treated was 57%) of high values after 1, 2, and 4 weeks implantation, respectively. The connective tissue did not intervene between a bone and an implant, and the direct-contact existed at the high rate. Therefore, it was suggested that this treatment was the method which obtained high bond-strength from the early stages after implantation.To examine the bonding strength between the titanium implant and the bone, the hydrothermal-treated implant specimen in calcium chloride solution was implanted in the tibia of the rat and pulling-out test was carried out. The bonding strength of hydrothermal-treatment titanium implant using calcium chloride solution indicated 1N/mm^2 and 1.7N/mm^2 for 1 and 4 weeks after implantation, respectively, and it became clear that the strength of hydrothermal-treated specimen after 1 week was equal to that of non-treated specimen after 4 weeks.This treatment could expect to be the epoch-making surface modification method, with "the resistance of micro-movement at the early stage", "possibility of the load at the early stage", "possibility of the substantial shortening of the healing-up period", and "expression of a high bonding-strength".

作者发现，用10-20mmol/L氯化钙水溶液在200℃下对钛种植体进行水热处理，可在种植体表面形成含有少量Ca的氧化钛膜，从而促进骨样磷灰石的生成以及成骨细胞的初步附着和增殖。另外，将在10～20mmol/L的氯化钙水溶液中进行水热处理的钛植入物植入大鼠的胫骨，检查植入物与骨的连接状况。结果显示，骨接触率为55％(未处理时为5.7％)、86％(未处理时为19.2％)、96％(未处理时为19.2％)。植入 1、2 和 4 周后，未经治疗的（未治疗的）分别为高值的 57%）。骨与种植体之间没有结缔组织介入，直接接触率很高。因此，表明这种处理是从植入后早期就获得高结合强度的方法。为了检查钛种植体与骨之间的结合强度，将在氯化钙溶液中水热处理的种植体样本植入大鼠胫骨中并进行拔出试验。使用氯化钙溶液进行水热处理的钛种植体在植入后1周和4周内的结合强度分别为1N/mm^2和1.7N/mm^2，并且很明显，经过水热处理的样品在1周后的强度与未处理样品在4周后的强度相当。这种处理有望成为划时代的表面改性方法，具有“ 早期阶段的微移动”、“早期阶段的负荷的可能性”、“愈合时间的大幅缩短的可能性”、以及“高粘合强度的表现”。