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A Study on the intravenous sedation with propofol - Function of Swallowing, BIS monitor and blood concentration of propofol -

异丙酚静脉镇静研究-吞咽功能、BIS监测及异丙酚血药浓度-

基本信息

批准号：
16591997
负责人：
SHIMADA Masahiko
金额：
$ 2.37万
依托单位：
OKAYAMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591997/
关键词：
Intravenous sedation Function of Swallowing tongue pressure pharyngeal pressure Dental treatment BIS Blood concentration Pronofol 舌骨上筋群

项目摘要

Purpose : The tongue contacts to the hard palate during the pharyngeal stage of swallowing. This is essential for swallowing safety. Purpose of this study is to make up a system to measure the pressure of tongue and pharynx at a time.Methods : Ten healthy volunteers (four male and six female) with mean age of 25.5 years old (range 20-34 years old) were examined. The infusion type pressure measuring and analyzing system PowerLab (ADInstrument inc.) was used. The micro silicon tubes (IMG inc.) were installed into the experimental palatal plate for the tongue pressure sensors at the four points to measure the pressure of the four section of the tongue ; anterior (Ch.1), middle (Ch.2), posterior (Ch.3) and right or left lateral (Ch.4) sections of tongue. The manometer had some sensors to measure the pressure at the upper esophageal and the 5mm upper point from it. With this system, we measured the tongue and pharyngeal pressure during swallowing saliva.Results : The mean of the maximal pressure and the occurring timing of the pressure of each measuring points were analyzed. The subjects were identified 4 patterns by the rank order of the maximal value. Tongue pressure almost always appeared simultaneously with pharyngeal pressures appearance.Conclusion : The intra-individual variation of the pressure was small, and we identified 4 types of swallowing pressure. The occurring timing of the pressure was suggested that contact of the tongue against the hard palate affect to pharyngeal stage.

目的：在吞咽的咽部阶段，舌头与硬腭接触。这对吞咽安全至关重要。方法：10名健康志愿者（男4名，女6名），年龄20-34岁，平均25.5岁。介绍了美国ADInstrument公司生产的输液式压力测量分析系统PowerLab。用了微型硅管（IMG Inc.）将舌压传感器安装在实验腭板上的四个点上，以测量舌的四个部分：前（Ch.1）、中（Ch.2）、后（Ch.3）和右或左外侧（Ch.4）。该压力计具有多个传感器，用于测量食道上部及其上方5 mm处的压力，利用该系统测量了吞咽唾液时的舌压和咽压。结果：分析了各测量点最大压力的平均值和压力发生的时间。受试者根据最大值的排序被识别为4种模式。舌压几乎总是与咽压同时出现。结论：吞咽压力的个体差异很小，我们确定了4种类型的吞咽压力。压力的出现时间提示舌与硬腭的接触对咽期有影响。