Development of the method of treatment for neuropathic pain -Basic study of the effect of iontophoresis-

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This study aimed to compare the effect of alternating current iontophoresis (AC IOP) with direct current iontophoresis (DC IOP). As a result of behavior and immunohistological experiment, DC IOP have a fast onset time and a short effect time, while AC IOP have a slow onset time and a long effect time. According to the result of the blood concentration of lidocaine, we confirmed that those effects were not caused by systemic administration of lidocaine. Additionally, those electrical powers we applied did not lead to extravasation of Evans Blue in the skins under the electrodes.Thus, these findings of this study suggest that AC IOP is useful for patients suffering from chronic pain because of its long effect time.