A Study on the intravenous sedation with propofal - BIS monitor and blood concentration of propofol

1.12名健康志愿者静脉注射异丙酚，剂量为6 mg/kg/h，连续5min。3 mg/kg/h，85min。用BIS监护仪评价镇静效果，并对其平衡功能进行定性和定量检测。在研究期间，BIS的值与镇静评分相关。2.为探讨BIS监测仪在静脉镇静中的应用价值，对10例智障患者在异丙酚静脉镇静下牙科治疗中应用BIS监护仪进行镇静效果评价。牙科治疗后BIS值与苏醒时间相关，提示BIS监测仪在牙科治疗中异丙酚静脉镇静的镇静效果评价中具有重要价值。

1.Twelve healthy volunteers who received intravenous administration of propofol at a dose of 6mg/kg/h for 5min. And 3mg/kg/h for 85min. Were evaluated sedative effect using BIS monitor and tested qualitatively and quantitatively for their equilibrium function. The values of BIS were correlated with sedation scores during the study. The recovery of equilibrium function were not complete though the value of BIS were normal.2.To investigate the usefulness of BIS monitor during intravenous sedation, ten patients with intellectual disability were evaluated sedative effect using BIS monitor during dental treatment under intravenous sedation with propofol. The values of BIS after dental treatment were correlated with recovery time.The results of study suggest that BIS monitor is very useful to evaluate the sedative effect under the intravenous sedation with propofol during the dental treatment.