A Study on the intravenous sedation with propofal - BIS monitor and blood concentration of propofol

丙泊酚静脉镇静-BIS监测及丙泊酚血药浓度研究

• 批准号: 13672095
• 负责人: SHIMADA Masahiko
• 金额: $ 2.18万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672095/
• 关键词: Intravenous sedation; Propofal; BIS monitor; Blood concentration; Equilibrium Function; Intellectual Disability; Dental treatment

1.Twelve healthy volunteers who received intravenous administration of propofol at a dose of 6mg/kg/h for 5min. And 3mg/kg/h for 85min. Were evaluated sedative effect using BIS monitor and tested qualitatively and quantitatively for their equilibrium function. The values of BIS were correlated with sedation scores during the study. The recovery of equilibrium function were not complete though the value of BIS were normal.2.To investigate the usefulness of BIS monitor during intravenous sedation, ten patients with intellectual disability were evaluated sedative effect using BIS monitor during dental treatment under intravenous sedation with propofol. The values of BIS after dental treatment were correlated with recovery time.The results of study suggest that BIS monitor is very useful to evaluate the sedative effect under the intravenous sedation with propofol during the dental treatment.

1. 12名健康志愿者接受丙泊酚6 mg/kg/h持续5 min静脉给药。3 mg/kg/h持续85 min。采用BIS监测仪评价镇静效果，并对平衡功能进行定性和定量检测。研究期间BIS值与镇静评分相关。为探讨BIS监测在静脉镇静中的应用价值，对10例智残患者在牙科治疗过程中应用BIS监测异丙酚静脉镇静效果。治疗后BIS值与清醒时间相关，提示BIS监测对口腔治疗中丙泊酚静脉镇静效果的评价有重要意义。

项目成果

北 ふみ: "プロポフォールを用いた静脈内鎮静法の回復過程の検討"岡山歯学会雑誌. 22(1)(印刷中). (2003)

Fumi Kita：“使用异丙酚静脉镇静后的恢复过程的研究”冈山牙科学会杂志 22(1)（出版中）。

Fumi KITA: "Determination of propofol in blood by HPLC"The Journal of Okayama Dental Society. 21(2). 191-194 (2002)

Fumi KITA：“用 HPLC 测定血液中的异丙酚”冈山牙科学会杂志。

北 ふみ: "高速液体クロマトグラフィーを用いた血中プロポフォールの測定について"岡山歯学会雑誌. 21(2). 191-194 (2002)

Fumi Kita：“使用高效液相色谱法测量血液中的异丙酚”，冈山牙科学会杂志 21(2) (2002)。

Fumi KITA: "A Study on Recovery from intravenous Sedation with Propofol"The Journal of Okayama Dental Society. 22(1) In press. (2003)

Fumi KITA：“异丙酚静脉镇静恢复的研究”冈山牙科学会杂志。

北 ふみ: "静脈内鎮静法におけるプロポフォールの投与方法の検討"岡山歯学会雑誌. 21(2). 195-200 (2002)

Fumi Kita：“静脉镇静中异丙酚给药方法的研究”冈山牙科学会杂志 21（2）195-200（2002）。