The relationship between pupil dilation response to noxious stimulation and defense response

人类的瞳孔在受到越来越多的有害刺激时明显扩大。然而，一个核心的未解决的问题是，这种瞳孔扩张反应（PDR）是否是脊髓交感反射。我们之前的报告显示,PDR可能brain-mediated响应防御反应等,并分析了两个实验:实验一:我们检查了PDR振幅是否增加了意想不到的刺激(B, C, D)相比预期刺激(a)结果:PDR的振幅D相比显著增加,A.Experiment 2:我们检查是否PDR的振幅,9月期间减少异丙酚镇静(0.3,0.6,0.9μg / ml p = 0.3, 0.6便士,0.9 p)结果:1。与对照组相比，0.6P、0.9P时对有害刺激的SEP振幅显著降低。与对照组相比，0.9P时强刺激的PDR幅值显著降低。与对照组相比，0.9P时VAS评分明显降低。BIS值与PDR、SEP、VAS呈正相关。我们得出结论，PDR对有害刺激(1)的振幅随着焦虑的增加而增加。(2)是疼痛的客观参数。(3)是判断镇静程度的客观参数。(4)是一个更复杂的大脑反应。

The pupil dilates markedly in response to increasing noxious stimulation in humans. However, a central unresolved issue is whether this pupil dilation response (PDR) is a spinal sympathetic reflex or not. Our previous reports indicate that the PDR could be a brain-mediated response such as a defense response, and examined two experiments as follows :Experiment 1 : We examined whether PDR amplitude is increased by unexpected stimuli(B,C,D) compared to expected stimuli(A)Result : The amplitude of PDR to D significantly increased compared to that to A.Experiment 2 : We examined whether the amplitude in PDR,SEP are decreased during propofol sedation(0.3,0.6,0.9μg/ml=0.3P、0.6P、0.9P)Result :1. The amplitude of SEP to noxious stimulation during 0.6P,0.9P significantly decreased compared to that to control.2. The amplitude of PDR to strong stimulation during 0.9P significantly decreased compared to that to control.3. The VAS during 0.9P significantly decreased compared to that to control.4. BIS value were positively related to PDR,SEP and VAS with strong stimulation.We concluded that PDR to noxious stimulation(1) increases the amplitude with increasing anxiety.(2) is an objective parameter for pain.(3) is an objective parameter for sedation level.(4) is a more complex brain response.