Analysis of biological malignancy in early stage HCC using low MI contrast ultrasound and angiogenesis factors.

使用低 MI 对比超声和血管生成因子分析早期 HCC 的生物恶性肿瘤。

• 批准号: 17500336
• 负责人: IIJIMA Hiroko
• 金额: $ 2.24万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17500336/
• 关键词: contrast ultrasound; microbubble; Neovascularize; hepatocellular carcinoma

PUROPOSE: We have performed visualization of hepatic microcirculation using a new modality of contrast ultrasound, Micro Flow Imaging (MFI) composed of a flash replenishment and maximum intensity holding sequences.MTHODS and MATERIALS: Flash replenishment imaging is an imaging mode which visualizes a re-perfusion of microbubbles with a harmonic ultrasound of a low mechanical index (MI) after destruction of microbubbles with a short time high MI ultrasound exposure. We combined the replenishment imaging with a maximum intensity holding sequence and it is called as MFI, in which the maximum signal reaching at an imaging pixel is hold and images are overlayed. We applied this technique to visualization of neovascularized microcirculation of hepatocellular carcinoma (HCC). The contrast agents used were SonoVue. The subjects were 54 patients with HCCs. The tumor size was ranged from 1 to 5cm and the average was 2.5cm.RESULTS: Hepatic vasculature was opacified with contrast media continuousl … More y until the terminal branches of the neovascularized tumor vessels. The minimum size was 200 μm or less. Tumor vessels of HCC were 1) irregularity in the caliber, 2) tortuosity of traveling and 3) heterogeneity of vascular distribution. These findings were categorized into three patterns. One is "cotton pattern", second "vascular pattern" and the third is "dead branch patter". Pathological findings were compared to these MFI patterns. The "cotton pattern" was often seen in well differentiated HCC, the "vascular pattern" in moderately differentiated HCC and the "dead branch patter" in poorly differentiated HCC. Manifestation of MFI was explained by biological features of neovascularization and vascular invasion according to the histological differentiation.CONCLUSIONS: It has been successfully performed to visualize tumor microcirculation using the MFI sequence, which has not been observed using conventional imaging modalities. Neovascularized tumor vessels were characteristically recognized and it is suggested that this technique will contribute greatly to clinical diagnosis of biological malignant features of HCCs. Less

嘌呤：我们已经进行了可视化的肝脏微循环使用一种新的方式的对比超声，微流成像（MFI）组成的闪光补给和最大强度holdingsequences.MTHODS和材料：闪光补给成像是一种成像模式，可视化的再灌注的微泡与谐波超声的低机械指数（MI）后，破坏微泡与短时间高MI超声曝光。我们结合了最大强度保持序列的补充成像，它被称为MFI，其中到达成像像素的最大信号被保持并且图像被叠加。我们应用这项技术来显示肝细胞癌（HCC）的新生血管微循环。使用的造影剂为SonoVue。研究对象为54例HCC患者。结果：造影剂连续显影，肝血管显影不明显，肿瘤直径1 ~ 5cm，平均2.5cm。 ...更多信息 y直至新生血管化肿瘤血管的终末分支。肝癌的肿瘤血管1）管径不规则，2）走行曲折，3）分布不均。这些发现分为三种模式。一是“棉花型”，二是“维管型”，三是“死分支型”。将病理学发现与这些MFI模式进行比较。“棉花样”多见于高分化肝癌，“血管样”多见于中分化肝癌，“死分支样”多见于低分化肝癌。根据组织学分化，用新生血管和血管浸润的生物学特征解释了MFI的表现。结论：使用MFI序列可以成功地显示肿瘤微循环，这是使用常规成像方式无法观察到的。新血管化的肿瘤血管被特征性地识别，这表明该技术将大大有助于临床诊断肝癌的生物学恶性特征。少

项目成果

【局所療法後,増殖,転移が誘発された症例】膵頭十二指腸切除後肝転移を来し局所療法などで5年間の治療経過を有する膵腺房細胞癌の1例

【局部治疗后诱发增殖转移一例】胰腺腺泡细胞癌胰十二指肠切除术后发生肝转移，局部治疗5年。

• 发表时间: 2005
• 期刊: Liver Cancer 11(1)
• 作者: 工藤 幸正;釜本 寛之;杉本 勝俊;目時 亮;小熊 一豪;鈴木 史朗;柳沢 京介;清水 雅文;宮原 健夫;横井 正人;堀部 俊哉;飯島 尋子;森安 史典;福嶋 敬宜;向井 清;佐久間正祥
• 通讯作者: 佐久間正祥

Differrential diagnosis of pancreatic tumors using ultrasound contrast imaging.

使用超声对比成像对胰腺肿瘤进行鉴别诊断。

• 发表时间: 2005
• 期刊: J.Gastroenterol. 40・5
• 作者: Sofuni;A.;Iijima;H.et al.
• 通讯作者: H.et al.

微小気泡造影剤を使った造影超音波診断の現状と展望

微泡造影剂超声造影诊断现状与展望

• 发表时间: 2006
• 期刊: 肝臓 38・5
• 作者: 森安史典;飯島尋子
• 通讯作者: 飯島尋子

Visualization of the drainage veins with contrast-enhanced sonography was useful in diagnosis of small focal nodular hyperplasia

通过对比增强超声检查引流静脉的可视化有助于诊断小局灶性结节性增生

• 发表时间: 2006
• 期刊: J Ultrasound Med. 25(6)
• 作者: Tooru Kobayashi;et. al.;Iijima H
• 通讯作者: Iijima H

造影超音波によるNon-alcoholic Steatohepatitis(NASH)の診断.

使用超声造影诊断非酒精性脂肪性肝炎 (NASH)。

• 发表时间: 2005
• 期刊: 消化器科 40・1
• 作者: N.Mori;M.Uchida;A.Nozawa;H.Ide;飯島尋子 他
• 通讯作者: 飯島尋子 他