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The research for occurrence mechanism of a spinal cord damage and a protection law after Thoracic Vascular surgery-Analysis using a positron sign compound

The research for occurrence mechanism of a spinal cord damage and a protection law after Thoracic Vascular surgery-Analysis using a positron sign compound
胸血管手术后脊髓损伤发生机制及保护规律的研究——正电子征化合物分析
批准号:
17591464
负责人:
MORIOKA Kouichi
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006

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英文摘要
We developed a new metabolism function analysis way using a fresh brain tissue slice of a rat and a positron sign compound (dynamic positron autoradiography technique, dPAT) in this research and were estimating. In particular we got a [18F] FDG bustle as two-dimensional image information to brain slice before and after a low oxygen load and a low oxygen with no glucose load.We succeeded to make a section of a spinal cord using rats and dogs.The difference between the spinal cord and the brain is elucidated, and it's considered whether the cerebroprotection effect and the spinal cord protection effect are partial.The dPAT method cannot reproduce the complete ischemic spinal cord injury of in vivo. But operating the organization and temperature of the solution, it can change conditional setting, can analyze a characteristic of an obstacle for a multiple factor. There is a scientific feature and a creativity at this point. In the future, elucidation of occurrence mechanism of complicated ischemic spinal cord injury and development of the protection method are expected.
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