The research for occurrence mechanism of a spinal cord damage and a protection law after Thoracic Vascular surgery-Analysis using a positron sign compound

胸血管手术后脊髓损伤发生机制及保护规律的研究——正电子征化合物分析

• 批准号: 17591464
• 负责人: MORIOKA Kouichi
• 金额: $ 2.24万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591464/
• 关键词: Spinal cord protection; FDG; Thoracic aortic surgery; Cooling; 体外循環

We developed a new metabolism function analysis way using a fresh brain tissue slice of a rat and a positron sign compound (dynamic positron autoradiography technique, dPAT) in this research and were estimating. In particular we got a [18F] FDG bustle as two-dimensional image information to brain slice before and after a low oxygen load and a low oxygen with no glucose load.We succeeded to make a section of a spinal cord using rats and dogs.The difference between the spinal cord and the brain is elucidated, and it's considered whether the cerebroprotection effect and the spinal cord protection effect are partial.The dPAT method cannot reproduce the complete ischemic spinal cord injury of in vivo. But operating the organization and temperature of the solution, it can change conditional setting, can analyze a characteristic of an obstacle for a multiple factor. There is a scientific feature and a creativity at this point. In the future, elucidation of occurrence mechanism of complicated ischemic spinal cord injury and development of the protection method are expected.

在本研究中，我们利用大鼠新鲜脑组织切片和正电子标记化合物(动态正电子放射自显影技术，DPAT)建立了一种新的代谢功能分析方法并进行了评估。特别是，我们在低氧负荷和低氧无葡萄糖负荷前后的脑切片上获得了[18F]FDG的二维图像信息。我们用大鼠和狗成功地制作了脊髓切片。阐明了脊髓与脑的区别，并考虑了脑保护作用和脊髓保护作用的部分。DPAT方法不能再现体内完全的脊髓缺血损伤。但操作解的组织和温度，它可以改变条件设置，可以多因素分析障碍物的特征。在这一点上，有一个科学的特征和创造力。未来，复杂的缺血性脊髓损伤发生机制的阐明和保护方法的发展是值得期待的。