权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Role of infectious diseases in allergic rhinitis

传染病在过敏性鼻炎中的作用

基本信息

批准号：
17591776
负责人：
OKAMOTO Yoshitaka
金额：
$ 2.3万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591776/
关键词：
allergic rhintis cedar pollinosis Th1 cell Th2 cell upper respiratory infection 気道感染ウイルス鼻粘膜過敏性

项目摘要

Total Th1 cells and Th2 cells in the serum of the patients with Japanese cedar pollinosis were examined by a flow cytometric analysis. The number of total Th2 cells did not show any significant seasonal change during the year, however, the number of Th1 cells increased in May, after cedar pollen season, compared with that in January, just before cedar pollen spread season. The Th1 and Th2 cells specific for cry j, which is the major antigen of Japanese cedar pollen, were also analyzed by ELISPOT assay. The cry j specific Th2 cells increased during the pollen season and decreased during the off-season and was about 70% in January, just before pollen season, compared with that in May, after pollen season. The cry j specific Th1 cells were low and were detected in only 20% of patients.The high prevalence of upper respiratory infection was observed in the cedar pollen season and these infection would induce the increase of Th1 cells. The increased Th1 cells seemed not to contribute to the improvement of allergic symptoms but rather to the aggravation, when analysed by the nasal allergic diary of these patients.

应用流式细胞仪检测了日本柳杉花粉症患者血清中Th 1细胞和Th 2细胞的数量。Th 2细胞总数在一年中没有明显的季节变化，而Th 1细胞数量在5月份（花粉季后）比1月份（花粉季前）有所增加。用ELISPOT法分析了日本杉花粉主要抗原cry j的特异性Th 1和Th 2细胞。cryj特异性Th 2细胞在花粉季节增加，在花粉淡季减少，花粉季节前的1月份约为花粉季节后5月份的70%。cry j特异性Th 1细胞水平较低，仅20%的患者可检测到cry j特异性Th 1细胞，而上呼吸道感染的高发季节是雪松花粉季节，上呼吸道感染可引起Th 1细胞的升高。Th 1细胞的增加似乎并不有助于改善过敏症状，而是加重，当分析这些患者的鼻过敏日记。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

上気道の急性感染症と慢性感染症との違い

急性和慢性上呼吸道感染的区别

DOI：
发表时间：
2005
期刊：
JOHNS 21
影响因子：
0
作者：
N.Kunii;T.Tomemori.;堀口茂俊;岡本美孝
通讯作者：
岡本美孝

上気道感染とアレルギー性鼻炎

上呼吸道感染和过敏性鼻炎

DOI：
发表时间：
2006
期刊：
医学のあゆみ 216
影响因子：
0
作者：
國井直樹;留守卓也
通讯作者：
留守卓也

Influence of viral infection on the development of nasal hypersensitivity

病毒感染对鼻过敏发生的影响

DOI：
发表时间：
2005
期刊：
Clinical and Experimental Allergy 35
影响因子：
0
作者：
Y.Okamoto;Z.Matsuzaki;T.Matsuoka;S.Endo;H.Yamamoto;H.Chazono;S.Horiguchi;T.Hanazawa
通讯作者：
T.Hanazawa

Influence of viral infection on the development of nasal hypersensitivity.

病毒感染对鼻过敏发展的影响。

DOI：
发表时间：
2005
期刊：
Clinical and Experimental Allergy 37
影响因子：
0
作者：
Y.Okamoto;Z.Matsuzaki;T.Matsuoka;S.Endo;H.Yamamoto;H.Chazono;S.Horiguchi;T.Hanazawa;Y.Okamoto.;Yoshitaka Okamoto
通讯作者：
Yoshitaka Okamoto

The different characteristics observed between acute and chronic infectious diseases in the upper respiratory infection.

上呼吸道感染急、慢性传染病的不同特点。