Control of sepsis with heat shock protein induced by high PEEP

高 PEEP 诱导的热休克蛋白控制脓毒症

• 批准号: 17591885
• 负责人: INABA Hideo
• 金额: $ 2.37万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591885/
• 关键词: PEEP; sepsis; renal ischemia; heat shock proteins; HSP-72; hemoxidese-1; DJ-1; PARK7; 人口呼吸

Pretreatment with PEEP significantly attenuated the renal ischemia-reperfusion injuries in rats. This effect of PEEP was not solely attributed to the hemodynamic effects of PEEP. The PEEP administration increased HSP72-expressed cells in the kidney in time-and level-dependent manners. It remains uncertain whether the PEEP administration may induce other heat shock proteins in the renal cells. Pretreatment with high PEEP did not significantly influence either the plasma TNF-alpha, 11-6 and 11-10 levels or hemodynamic variables after endotoxin administration. In contrast, removal of cytokines with CTR column significantly decreased the mortality and attenuated the changes in hemodynamics and plasma cytokine levels in rat septic models. In critically ill patients, plasma HSP72 levels were not correlated with the application of PEEP. Heat shock protein may be useful to evaluate the prognosis in patient resuscitated from cardiac arrests.

PEEP预处理可明显减轻大鼠肾缺血再灌注损伤。PEEP的这种效应并不完全归因于PEEP的血流动力学效应。PEEP组大鼠肾脏HSP 72表达细胞数呈时间和水平依赖性增加。目前尚不确定PEEP是否会诱导肾细胞中的其他热休克蛋白。高PEEP预处理对血浆TNF-α、11 - 6和11 - 10水平或内毒素给药后的血流动力学变量均无显著影响。相比之下，CTR柱去除细胞因子显著降低了大鼠脓毒症模型的死亡率，并减轻了血流动力学和血浆细胞因子水平的变化。在危重患者中，血浆HSP 72水平与PEEP的应用无关。热休克蛋白可用于评估心脏骤停复苏患者的预后。

项目成果

Dose-related effects of direct hemoperfusion using a cytokine adsorbent column for the treatment of experimental endotoxemia

使用细胞因子吸附柱直接血液灌流治疗实验性内毒素血症的剂量相关效应

• 发表时间: 2007
• 期刊: Intensive Care Med 33.3
• 作者: Taniguchi T;Kurita A;Mukawa C;Yamamoto K;Inaba H
• 通讯作者: Inaba H

A novel adsorbent of circulating bacterial toxins and cytokines : The effect of direct hemoperfusion with CTR column for the treatment of experimental endotoxemia.

循环细菌毒素和细胞因子的新型吸附剂：CTR柱直接血液灌流治疗实验性内毒素血症的效果。

• 发表时间: 2006
• 期刊: Crit Care Med 34・3
• 作者: Taniguchi T;Hirai F;Takemoto Y;Tsuda K;Yamamoto K;Inaba H;et al.
• 通讯作者: et al.

Effects of post-treatment with direct hemoperfusion using a CTR column on mortality and inflammatory responses to endotoxin-induced shock in rats.

使用 CTR 柱进行直接血液灌流后处理对大鼠内毒素诱导休克的死亡率和炎症反应的影响。

• 发表时间: 2006
• 期刊: Blood Purification 24.5-24.6
• 作者: Taniguchi T;Takemoto Y;Tsuda K;Inaba H;et al.
• 通讯作者: et al.

A nobel adsorbent of circulating bacterial toxins and cytokines

循环细菌毒素和细胞因子的诺贝尔吸附剂

• 发表时间: 2006
• 期刊: Crit Care Med 34・3
• 作者: Taniguchi T;Takemoto Y;Tsuda K;Inaba H;et al.;Taniguchi T
• 通讯作者: Taniguchi T

Dose-related effects of direct hemoperfusion using a cytokine adsorbent column for the treatment of experimental endotoxemia.

使用细胞因子吸附柱直接血液灌流治疗实验性内毒素血症的剂量相关效应。

• 发表时间: 2007
• 期刊: Intensive. Care Med 33・3
• 作者: Taniguchi T;Kurita A;Mukawa C;Yamamoto K;Inaba H
• 通讯作者: Inaba H