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Pathways and fate of epithelial root sheath cells during cementogenesis in rat incisors

Pathways and fate of epithelial root sheath cells during cementogenesis in rat incisors
大鼠门牙牙骨质形成过程中上皮根鞘细胞的途径和命运
批准号:
17591903
负责人:
KAWANO Yoshiro
金额:
$2.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006

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中文摘要
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英文摘要
It is well known that the epithelial root sheath is greatly involved in the root dentin formation and the development of periodontium. Two possibilities on the fate of epithelial root sheath cells are proposed, the pathway to be extinguished by the apoptosis, and the pathway to transform into cementblasts by epithelio-mesenchymal transformation. Phenotypic transformation from the epithelial cell into the mesenchymal cell is reported in developing Muellerian duct and the epithelial cells in the median palatine suture, and recognized in the transformation from cancer cells into invasive metastatic cells in a pathogenic case.The origin of cementblastic cells remains controversial. Mature cementblasts produce matrix proteins common to osteoblasts, such as Type I collagen, osteocalcin, and osteopontin. These features led to the suggestion that the cementblasts are uniquely positioned osteoblasts. On the other hand, morphological data and the expression in some cementblasts of dental epithel … More ium markers, such as karatin, E-cadherin and amelin/ameloblastion/sheathlin, support the hypothesis that root epithelium-derived cells also persist during cementum formation. These findings support the epithelial-mesenchymal transformation hypothesis that epithelial root sheath cells differentiate into cementoblasts. However, to date, the spatial-temporal behavior of epithelial root sheath cells and its mechanism has not been elucidated.The immunohistochemisty demonstrated that a certain kind of heat shock protein was expressed continuously from the epithelial cells to the cementblasts on the root dentin and that a certain kind of aquapolin and S100 protein were expressed in the cementoblasts in the rat incisor. The expression pattern of these proteins during cementum formation illustrates the complex origin of cementblasts and the fate of epithelial root sheath cells. These results suggest mesenchymal transition in odontogenic epithelium and the importance of these proteins during the cement genesis. Less
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Characteristic distribution of immunoreaction for estrogen receptor alpha (ERα) in rat ameloblasts
大鼠成釉细胞雌激素受体α(ERα)免疫反应的特征分布
DOI: --
发表时间: 2005
期刊: Anat.Rec. 284A
影响因子: --
作者: [Simamura, E., Ferrer V-L et al., Ferrer V-L et al.]
通讯作者: Ferrer V-L et al.
Immunolocalization of aquaporin1 on the interfaces between tissues with different physical properties
  • 批准号:
    24592761
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.49万
  • 财政年份:
    2012
  • 负责人:
    KAWANO Yoshiro
  • 依托单位:
Morphological analysis of cementogenesis using a newly identified cementoblast specific marker
  • 批准号:
    21592322
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2009
  • 负责人:
    KAWANO Yoshiro
  • 依托单位:
Identification of gene expressions during rat amelogenesis using ACPDD RT-PCR method
  • 批准号:
    19592106
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2007
  • 负责人:
    KAWANO Yoshiro
  • 依托单位:
Possible Roles of Shh in Ameloblast differentiation
  • 批准号:
    15591927
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.24万
  • 财政年份:
    2003
  • 负责人:
    KAWANO Yoshiro
  • 依托单位:
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  • 批准号:
    HDMZ25H160002
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2025
  • 负责人:
    梁岳龙
  • 依托单位:
内皮细胞基质蛋白CCN5通过整合素α3β 1及s100 a8/a9通路调控血管新生作用与机制研究
经颅多普勒超声及S100β、NSE蛋白综合监测对预测动脉瘤术后脑血管痉挛及迟发性脑缺血的意义
  • 批准号:
    2022J011495
  • 项目类别:
    省市级项目
  • 资助金额:
    9.9万元
  • 批准年份:
    2022
  • 负责人:
    张春林
  • 依托单位:
吞噬细胞特异性促炎蛋白S100/Calgranulins与缺血性脑卒中预后关系的前瞻性队列研究
  • 批准号:
    82103921
  • 项目类别:
    青年科学基金项目(C类)
  • 资助金额:
    30.0万元
  • 批准年份:
    2021
  • 负责人:
    郭道遐
  • 依托单位: