Star and Amphiphilic Responsive Anisotropic Colloids: Design and Self-Assembly

具有可调星型结构的杂化胶体将由生物工程丝状fd病毒设计而成，这些病毒作为臂，专门与热响应微凝胶相关联，作为星型嵌段共聚物的中尺度模拟物。这些新的胶体聚合物的形成依赖于亚琛在功能微凝胶及其作为模型软胶体方面的互补专业知识，以及波尔多在棒状病毒及其尖端功能化方面的专业知识。得益于杆状病毒的大持续长度，这种胶体共聚物有望提供一种新的极远距离软电位和丰富的相图，将在直接和互反空间结合显微镜和散射技术进行研究。这些具有可调病毒臂空间分布的胶体聚合物星将允许在单颗粒尺度上进行动力学研究。最后，通过将价键降低到一个病毒与一个微凝胶相连，或通过特异性功能化微凝胶，两亲性杂交体将产生，最终目标是创造模仿分子系统的胶体类似物，并在嵌段共聚物和表面活性剂的单颗粒水平上观察到。根据它们的有效填充参数，这些两亲性胶体将自组织成定义的分层组合，如球形、蠕虫状或水泡状的超结构，为更好地理解它们的自组装过程和相变开辟了道路。

Hybrid colloids with tunable star architectures will be designed from bioengineered filamentous fd viruses acting as arms specifically associated with thermo-responsive microgels as a mesoscale analog of star block copolymers. The formation of these new colloidal polymers relies on the complementary expertise of Aachen on functional microgels and their use as model soft colloids and Bordeaux on rod-like viruses and their tip functionalization. Benefiting from the large persistence length of the rod-shaped virus, such colloidal copolymers are expected to offer a novel extremely long-range soft potential and a rich phase diagram that will be investigated both in the direct and reciprocal space combining microscopy and scattering techniques. These colloidal polymer stars with tunable spatial distribution of the viral arms will allow for dynamics study at the single particle scale. Finally, by reducing the valency to one virus linked to one microgel or by specifically functionalizing the microgels, amphiphilic hybrids will be produced with the ultimate goal to create colloidal analogs mimicking molecular systems and being observable at the single particle level of block copolymers and surfactants. According to their effective packing parameters, these amphiphilic colloids will self-organize into defined hierarchical assemblies, as spherical, worm-like or vesicular superstructures, opening the way of a better understanding of their self-assembly processes and phase transitions.