Evolution of eudicots quantitative disease resistance to necrotrophic fungal pathogens

真双子叶植物对坏死性真菌病原体定量抗病性的进化

基本信息

项目摘要

ResiDevo aims to understand the mechanisms underlying the diversity and evolution of disease resistance to necrotrophic fungal pathogens in plants. Our key hypothesis, derived from our preliminary data and evolutionary theories is thatmany QDR genes evolved early in Angiosperm evolution and acquired diversified modes of regulation to create diversified QDR responses in modern plant populations. The immediateobjective of this proposal is to compare global responses to necrotrophic fungi in plants from two botanical families to infer general rules underlying the diversification of these responsesat various evolutionary scales (intra and inter specific). We address four main objectives using comparative analyses in plant species from the Brassicales (Arabidopsis thaliana and others)and Solanales (Solanum chilense and others) and two Ascomycete pathogens with similar lifestyle (necrotrophic, foliar, asexual) and contrasted host range (generalist and specialist) as tractable organisms for this approach.We will: 1) Characterize intra and inter specific variation in the plant QDR phenotypes and identify major resistance Quantitative Trait Loci (QTLs). 2) Document the diversity of transcriptional reprogramming during QDR at different levels: species, family, order. 3) Study the evolution of sequence and expression for genes responsive to fungal pathogens at the population, genus and family levels, and 4) Validate key components of QDR in Brassicales and Solanales and study the genome scale impact of transcription factors recruitment into QDR.This interdisciplinary work will generate unprecedented datasets for evolutionary studies of plant‐microbe interactions including: 1) Phenotypic diversity on a comparable scale for plants covering the population, genus and family levels inoculated by fungi from two distinct Classes of the Ascomycetes. 2) A so far unique transcriptomics dataset allowing to test a number of key theoretical predictions and to mine for genes contributing to the QDR phenotype across species 3) Complete evolutionary analyses of pathogen‐responsive genes in several plant lineages, and 4) In depth functional characterization of the role of a few transcription factors in QDR and the genome-scale consequences of their natural sequence/regulatory diversificationResiDEvo will lead to conceptual advances on the evolution of the plant immune system. It will it will identify and validate the role of novel resistance mechanisms conserved across two botanical families and offer promising applied perspectives thanks to data generated on included cultivated species.
ResiDevo旨在了解植物对坏死性真菌病原体的抗病性的多样性和进化的机制。根据我们的初步数据和进化理论,我们的主要假设是,许多QDR基因在被子植物进化的早期就进化了,并获得了多样化的调控模式,从而在现代植物种群中产生了多样化的QDR反应。该建议的直接目标是比较全球的反应,从两个植物科的植物necrotrophic真菌推断的一般规则,这些responsesat不同的进化尺度(内和种间)的多样化。我们解决了四个主要目标,利用比较分析植物物种从紫云英目(拟南芥等)和茄目(Solanum chilense等)和两种生活方式相似的子囊菌病原体(坏死营养型、叶型、无性型)和对照寄主范围(通才和专家)作为这种方法的易驾驭的有机体。我们将:1)表征植物QDR表型中的种内和种间变异并鉴定主要抗性数量性状基因座(QTL)。2)在不同的水平上记录QDR期间转录重编程的多样性:种,科,目。3)在种群、属和科的水平上研究响应真菌病原体的基因的序列和表达的进化,以及4)研究拟南芥目和茄目中QDR的关键组分,并研究转录因子招募到QDR中的基因组规模影响。这项跨学科的工作将为植物微生物相互作用的进化研究产生前所未有的数据集,包括:1)覆盖由来自子囊菌纲的两个不同纲的真菌接种的种群、属和科水平的植物在可比尺度上的表型多样性。2)迄今为止唯一的转录组学数据集,允许测试许多关键的理论预测,并挖掘有助于跨物种的QDR表型的基因3)几种植物谱系中病原体响应基因的完整进化分析,和4)深入功能表征的作用,一些转录因子在QDR和基因组规模的后果,他们的天然序列/Regulatory diversificationResiDEvo将导致植物免疫系统进化的概念性进展。它将识别和验证两个植物科中保守的新抗性机制的作用,并通过所包含的栽培物种产生的数据提供有希望的应用前景。

项目成果

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Professor Dr. Remco Stam其他文献

Professor Dr. Remco Stam的其他文献

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{{ truncateString('Professor Dr. Remco Stam', 18)}}的其他基金

Pathogen adaptations to host and climate in a wild plant-pathosystem
野生植物病理系统中病原体对宿主和气候的适应
  • 批准号:
    403835372
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Grants
The evolution of the RLP gene family in wild tomato species
野生番茄中 RLP 基因家族的进化
  • 批准号:
    516659121
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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Mitochondrial genomics of mycoheterotrophic eudicots
真菌异养真双子叶植物的线粒体基因组学
  • 批准号:
    512967-2017
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    University Undergraduate Student Research Awards
Functional diversification of class1 KNOX genes in basal eudicots
基础真双子叶植物 1 类 KNOX 基因的功能多样化
  • 批准号:
    19309724
  • 财政年份:
    2005
  • 资助金额:
    --
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    Research Grants
Duplicate Genes and Plant Phylogeny: Phytochromes and the Rooting of Seed Plants, Angiosperms, and Eudicots
重复基因和植物系统发育:光敏色素和种子植物、被子植物和真双子叶植物的生根
  • 批准号:
    0196150
  • 财政年份:
    2000
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Duplicate Genes and Plant Phylogeny: Phytochromes and the Rooting of Seed Plants, Angiosperms, and Eudicots
重复基因和植物系统发育:光敏色素和种子植物、被子植物和真双子叶植物的生根
  • 批准号:
    9806937
  • 财政年份:
    1998
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
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