Disentangling the link between emotion regulation and binge eating in binge eating disorder

先前的证据表明，情绪调节（ER）在暴食症（BED）中与奖励相关的食物摄入密切相关。然而，内啡肽与BED患者暴饮暴食之间的联系机制在很大程度上尚不清楚。与此同时，来自其他领域的基础研究一再表明，在适应性（非适应性）ER策略的使用下，认知控制得到了改善（降低）。本项目的目的是研究雌激素对暴饮暴食的影响是否通过其对食物相关认知控制的影响来介导。我们假设适应性内源性雌激素增加了与食物相关的认知控制，从而减少了BED患者的暴食发作。首先，在两周的时间内，我们将使用多场合评估（EMA）来调查在一个大型BED样本中，ER技能应用、食物相关认知控制（使用既定的反应时间范式）和随后的暴食发作之间的滞后关联。其次，为了测试因果关系，我们将进行一个基于实验室的实验，在这个实验中，我们将在消极情绪诱导后操纵ER。与食物相关的认知控制以及虚假味觉测试中的食物摄入将是结果测量。

Previous evidence suggests that emotion regulation (ER) is strongly involved in reward-related food intake in binge eating disorder (BED). However, the mechanisms that link ER to binge eating in BED are largely unclear. At the same time, fundamental research from other domains has repeatedly shown an improved (reduced) cognitive control under usage of adaptive (maladaptive) ER strategies.The aim of the present project is to investigate whether the effect of ER on binge eating is mediated by its effects on food-related cognitive control. We assume that adaptive ER increases food-related cognitive control and thereby reduces binge episodes in individuals with BED.First, using multiple occasion assessment (EMA) over a period of two weeks we will investigate time-lagged associations between ER skills application, food-related cognitive control (using an established reaction-time paradigm) and subsequent binge episodes in a large BED sample. Second, to test for causal links, we will conduct a laboratory-based experiment, in which we will manipulate ER following a negative mood induction. Food-related cognitive control as well as food intake in a bogus taste test will be the outcome measures.