Medical bone glues on the basis of calcium phosphate nanoparticles

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In general, there is an urgent clinical demand for adhesives that are able to effectively connect bone tissue. The currently available medical glues are not able to fulfil this task. The goal of this project is the development and synthesis of a paste based on calcium phosphate which is able to join bone fragments by gluing. To achieve this, the properties of the paste itself and together with bone will be investigated in a physiological environment. The paste is based on synthetically prepared calcium phosphate nanoparticles which are chemically modified to permit am internal cross-linking and a strong adhesion to bone tissue. At the end, we will have an adhesive that is mechanically stable in the moist bone environment, biologically degradable, and can join bone fragments in a moderately loaded defect. The glue must not block the contact area between two bone fragments because this would prevent their final joining by the formation of new bone. The glue shall last for about 3 months until the bone has biologically joined and healed.First, the calcium phosphate nanoparticles are surface-functionalized in different ways. Their biomechanical properties are assessed in the form of a paste. Accompanying biocompatibility tests with human cell lines and primary cells are performed. Finally, the effect of the calcium phosphate nanoparticles on bone resorption, bone generation, and angiogenesis is assessed. Finally, the calcium phosphate nanoparticles are tested in-vivo and the bone healing/stability are assessed in a gluing experiment. A goal is also a suitable degradation profile by osteoclasts without toxic degradation products and containment of the bone healing.