Low-modulus Ti-Nb alloys coated with sputter-deposited hydroxyapatite as biomaterial in bone contact

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Calcium phosphate-coated titanium-niobium alloys will be systematically explored as potential biomaterials in bone contact. Beta-phase Ti-Nb alloy samples in defined shape with different porosities will be prepared by additive manufacturing. The optimization of the Nb content in the range of 10-27 at% will be performed based on the criterion to match the Young modulus to that of cortical bone. The enhancement of a bioactive action in contact with bone will be accomplished by RF-magnetron sputter deposition of Sr- or Mg-doped hydroxyapatite (calcium phosphate). The surface chemistry and topography of the samples is expected to modulate cell adhesion, proliferation and growth for a better bone attachment. This coated material will be studied by in-vitro cell culture to derive the influence of the materials parameters, i.e. the composition of the metallic base material and the calcium phosphate coating. The goal is to have a parameter set for these metallic materials in bone contact, based on elastic Ti-Nb alloys (also porous) with a calcium phosphate coating to promote bone growth. Thus, fundamental insight into the combination of novel Ti-Nb alloys with bioactive calcium phosphate coatings for an application in bone contact will be obtained, opening the pathway for improved implants like endoprostheses or dental implants.