Low-modulus Ti-Nb alloys coated with sputter-deposited hydroxyapatite as biomaterial in bone contact

磷酸钙包覆钛铌合金将作为潜在的骨接触生物材料进行系统的探索。采用增材制造方法制备具有不同孔隙率的形状确定的β相Ti-Nb合金样品。根据杨氏模量与皮质骨的杨氏模量相匹配的标准，将Nb含量在10-27 at%范围内进行优化。通过射频磁控溅射沉积锶或镁掺杂羟基磷灰石（磷酸钙）来增强与骨接触的生物活性作用。样品的表面化学和形貌有望调节细胞的粘附、增殖和生长，以获得更好的骨附着。这种包被材料将通过体外细胞培养进行研究，得出材料参数的影响，即金属基材和磷酸钙包被的组成。目标是为这些金属材料在骨骼接触中设定一个参数，基于弹性Ti-Nb合金（也是多孔的）和磷酸钙涂层，以促进骨骼生长。因此，将获得新型Ti-Nb合金与生物活性磷酸钙涂层结合用于骨接触的基本见解，为改进种植体（如内假体或牙科种植体）开辟途径。

Calcium phosphate-coated titanium-niobium alloys will be systematically explored as potential biomaterials in bone contact. Beta-phase Ti-Nb alloy samples in defined shape with different porosities will be prepared by additive manufacturing. The optimization of the Nb content in the range of 10-27 at% will be performed based on the criterion to match the Young modulus to that of cortical bone. The enhancement of a bioactive action in contact with bone will be accomplished by RF-magnetron sputter deposition of Sr- or Mg-doped hydroxyapatite (calcium phosphate). The surface chemistry and topography of the samples is expected to modulate cell adhesion, proliferation and growth for a better bone attachment. This coated material will be studied by in-vitro cell culture to derive the influence of the materials parameters, i.e. the composition of the metallic base material and the calcium phosphate coating. The goal is to have a parameter set for these metallic materials in bone contact, based on elastic Ti-Nb alloys (also porous) with a calcium phosphate coating to promote bone growth. Thus, fundamental insight into the combination of novel Ti-Nb alloys with bioactive calcium phosphate coatings for an application in bone contact will be obtained, opening the pathway for improved implants like endoprostheses or dental implants.