Tailored silver nanoparticles (NPs) in biological environments: Interactions with biomolecules and cells (nano.ag)

生物环境中的定制银纳米颗粒 (NP)：与生物分子和细胞的相互作用 (nano.ag)

• 批准号: 57812932
• 负责人: Professor Dr. Matthias Epple
• 金额: --
• 依托单位: Physikalische Chemie - AG Zellner
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/57812932?language=en
• 关键词: Tailored; silver; nanoparticles; NPs; biological

Silver nanoparticles represent the class of nanoparticles with the highest commercial impact, being used in consumer commodities, textiles and medical equipment due to their bactericidal potential. The biological action of self-synthesized and thoroughly characterized silver nanoparticles will be investigated at various levels: Their interaction with biomolecules, their entrance into cells, the mechanism of their biological action, the dissolution under release of silver ions, and their fate in the cell after uptake and internalization. These investigations will be carried out under variation of the kind of surface functionalization and the size of the silver nanoparticles. For comparison, gold nanoparticles as a biologically inert material with the same surface functionalization and size will be tested by the same methods.

银纳米颗粒代表具有最高商业影响的纳米颗粒类，由于其杀菌潜力而用于消费商品，纺织品和医疗设备。将在各个层面上研究自同一化和彻底特征的银纳米颗粒的生物学作用：它们与生物分子的相互作用，进入细胞的进入，生物学作用的机制，释放的银离子下的溶解以及摄取后的细胞中的命运。这些研究将在表面功能化的种类和银纳米颗粒的大小的变化下进行。为了进行比较，将通过相同的方法测试具有相同表面功能和大小的生物惰性材料的金纳米颗粒。