Inflammation-driven Diseases Program (INDEEP): inflammatory response as driver for human diseases and target for therapy

通过INDEEP，法兰克福歌德大学的医学院致力于在临床医生科学家(CS)实习的早期阶段给予他们战略优势，并缩小医学院期间的结构化教学与一些现有的短期支持计划和针对临床培训高级阶段的计划之间的差距。英迪普将为我们的教师提供将临床和基础研究联系起来的激励措施，并支持一批具有强大基础和翻译研究背景的有才华的年轻临床医生。INDEEP的科学重点是炎症驱动的疾病，这些疾病对医学人员来说非常重要。为此，我们将与现场DFG资助的项目密切合作，如合作研究中心和研究单位。英迪普将在三年内支持12名早期职业CS。随着这一更大规模的招生，更多的新兴CS可以被录取，这一步骤对于为真正的临床医生科学家项目奠定基础至关重要，该项目有能力对歌德大学的临床研究基础设施产生重大影响。此外，INDEEP将更早开始，并提供比当前计划更长的受保护的研究时间，从而缩小与现有高级计划的差距，这些计划旨在实现更高级的职业阶段，从而允许更平稳地过渡到这些计划。最后，INDEEP将通过一个指导计划来扩大CS的科学资格，以促进有前途的参与者与临床住院医师一起和整合在临床实习中的科学竞争力，并在进入高级计划之前进行评估。随着INDEEP加入目前的项目，医务人员将能够在所有职业生涯阶段为CS提供炎症领域的支持，并为临床和科学职业生涯的决策提供指导。InDeep将使CS能够成功地竞争已经到位的不同高级临床医生科学家计划(ACS)的职位。为了将法兰克福的支持环境以及正在进行的基础研究与最大的医疗需求完美地结合在一起，INDEEP将专注于推动炎症的基本机制。这一主题将在以下四个科学重点领域中讨论：(I)传染病和纤维性疾病，(Ii)心血管疾病，(Iii)癌症和(Iv)神经精神障碍，所有这些领域都有记录在案，在我们的教员和整个歌德大学采用新的跨学科方法进行了出色的研究。因此，INDEEP的目标是：·在歌德大学医院推广炎症驱动疾病的概念·通过在不同职业阶段提供足够的职位，为歌德大学医院最好的CS创造长期前景·为CS的教育结构奠定基础

With INDEEP, the medical faculty at Goethe University Frankfurt is committed to grant clinician scientists (CS) a strategic advantage at an early phase of their residency and close the gap between the structured teaching during medical school and some existing short-term support programs, and the programs targeting advanced stages of clinical training. INDEEP will provide our faculty with an incentive to connect clinical and basic research and support a pool of talented young clinicians with a strong basic and translational research background. The scientific focus of INDEEP is on inflammation-driven diseases, which are of major importance to the medical faculty. To this end, we will work closely with on-site DFG-funded programs such as Collaborative Research Centers and Research Units. INDEEP will support twelve early career CS over a period of three years. With this larger intake, more emerging CS can be admitted a step that is essential to lay the foundation for a true clinician scientist program with the capacity to make a strong impact on the clinical research infrastructure at Goethe University. In addition, INDEEP will start earlier and provide longer protected research time than the current program and thereby close the gap to existing advanced programs, which aim at more advanced career stages, and thus allow for a smoother transition into those programs. Finally, INDEEP will expand the scientific qualification of the CS with a mentoring program to promote scientific competitiveness among promising participants alongside and integrated in clinical residency, with evaluation steps before entering the advanced programs. With the addition of INDEEP to the current programs, the medical faculty will be able to support CS in the area of inflammation at all career stages and provide guidance in decisions regarding clinical and scientific career. INDEEP will enable CS to successfully compete for positions in different advanced clinician scientist programs (ACS), which are already in place. To provide the best integration of the support landscape in Frankfurt as well as of the ongoing basic research with the biggest medical need, INDEEP will focus on basic mechanisms driving inflammation. This topic will be addressed in the following four scientific focus areas (i) infectious and fibrotic diseases, (ii) cardiovascular diseases, (iii) cancer and (iv) neuropsychiatric disorders, all of which have a documented track record of excellent research in our faculty and the entire Goethe University following novel interdisciplinary approaches. Therefore, the aims of INDEEP are to:• Promote the concept of inflammation-driven disease at Goethe University Hospital• Create long-term perspectives for the best CS at Goethe University Hospital by providing sufficient positions at different career stages• Lay the foundation for educational structures for CS