Inflammation-driven Diseases Program (INDEEP): inflammatory response as driver for human diseases and target for therapy

炎症驱动疾病计划 (INDEEP)：炎症反应作为人类疾病的驱动因素和治疗目标

• 批准号: 493624332
• 负责人: Professorin Dr. Evelyn Ullrich
• 金额: --
• 依托单位: Universitätsklinikum Köln
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/493624332?language=en
• 关键词: Inflammation; driven; Diseases; Program; INDEEP

With INDEEP, the medical faculty at Goethe University Frankfurt is committed to grant clinician scientists (CS) a strategic advantage at an early phase of their residency and close the gap between the structured teaching during medical school and some existing short-term support programs, and the programs targeting advanced stages of clinical training. INDEEP will provide our faculty with an incentive to connect clinical and basic research and support a pool of talented young clinicians with a strong basic and translational research background. The scientific focus of INDEEP is on inflammation-driven diseases, which are of major importance to the medical faculty. To this end, we will work closely with on-site DFG-funded programs such as Collaborative Research Centers and Research Units. INDEEP will support twelve early career CS over a period of three years. With this larger intake, more emerging CS can be admitted a step that is essential to lay the foundation for a true clinician scientist program with the capacity to make a strong impact on the clinical research infrastructure at Goethe University. In addition, INDEEP will start earlier and provide longer protected research time than the current program and thereby close the gap to existing advanced programs, which aim at more advanced career stages, and thus allow for a smoother transition into those programs. Finally, INDEEP will expand the scientific qualification of the CS with a mentoring program to promote scientific competitiveness among promising participants alongside and integrated in clinical residency, with evaluation steps before entering the advanced programs. With the addition of INDEEP to the current programs, the medical faculty will be able to support CS in the area of inflammation at all career stages and provide guidance in decisions regarding clinical and scientific career. INDEEP will enable CS to successfully compete for positions in different advanced clinician scientist programs (ACS), which are already in place. To provide the best integration of the support landscape in Frankfurt as well as of the ongoing basic research with the biggest medical need, INDEEP will focus on basic mechanisms driving inflammation. This topic will be addressed in the following four scientific focus areas (i) infectious and fibrotic diseases, (ii) cardiovascular diseases, (iii) cancer and (iv) neuropsychiatric disorders, all of which have a documented track record of excellent research in our faculty and the entire Goethe University following novel interdisciplinary approaches. Therefore, the aims of INDEEP are to:• Promote the concept of inflammation-driven disease at Goethe University Hospital• Create long-term perspectives for the best CS at Goethe University Hospital by providing sufficient positions at different career stages• Lay the foundation for educational structures for CS

通过INDEEP，法兰克福歌德大学的医学系致力于在住院医师的早期阶段为临床科学家（CS）提供战略优势，并缩小医学院期间的结构化教学与一些现有的短期支持计划之间的差距，以及针对临床培训高级阶段的计划。INDEEP将为我们的教师提供激励，以连接临床和基础研究，并支持有才华的年轻临床医生与强大的基础和转化研究背景池。INDEEP的科学重点是炎症驱动的疾病，这是非常重要的医疗机构。 为此，我们将与现场DFG资助的项目，如合作研究中心和研究单位密切合作。INDEEP将在三年内支持12个早期职业CS。有了这个更大的摄入量，更多的新兴CS可以被录取，这是必要的一步，奠定了一个真正的临床医生科学家计划的基础，使在歌德大学的临床研究基础设施的强大影响的能力。此外，INDEEP将比目前的计划更早开始，提供更长的受保护的研究时间，从而缩小与现有高级计划的差距，这些计划的目标是更高级的职业阶段，从而允许更顺利地过渡到这些计划。最后，INDEEP将通过指导计划扩大CS的科学资格，以促进有前途的参与者之间的科学竞争力，并与临床实习相结合，在进入高级课程之前进行评估。 随着INDEEP加入到目前的计划中，医学院将能够在所有职业阶段支持炎症领域的CS，并为临床和科学职业生涯的决策提供指导。INDEEP将使CS能够成功地竞争不同的高级临床医生科学家计划（ACS）的职位，这些计划已经到位。为了提供法兰克福支持景观的最佳整合，以及正在进行的基础研究与最大的医疗需求，INDEEP将专注于驱动炎症的基本机制。该主题将在以下四个科学重点领域进行讨论：（i）感染性和纤维化疾病，（ii）心血管疾病，（iii）癌症和（iv）神经精神疾病，所有这些都在我们的教师和整个歌德大学中有记录的优秀研究记录。因此，INDEEP的目标是：·在歌德大学医院推广炎症驱动疾病的概念·通过在不同职业阶段提供足够的职位，为歌德大学医院的最佳CS创造长期前景·为CS的教育结构奠定基础