Activation of dioxygen by copper complexes in water for the selective oxidation/oxygenation of organic substrates

水中铜配合物活化分子氧，用于有机底物的选择性氧化/充氧

• 批准号: 495326964
• 负责人: Professor Dr. Siegfried Schindler
• 金额: --
• 依托单位: Institut für Anorganische und Analytische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/495326964?language=en
• 关键词: Activation; dioxygen; copper; complexes; water

Selective oxidations of organic substrates such as e. g. cyclohexane are extremely important in chemical industry and in the laboratory. Up to now many of these reactions are performed in organic solvents applying oxidants that often are toxic or bad for the environment and/or expensive catalysts based on noble metals. Furthermore, most of the time it is necessary to run these reactions at higher temperatures and pressures. In contrast metalloenzymes, often monooxygenases with iron or copper ions at the active site are capable to perform these reactions under ambient conditions in water with dioxygen from air as an oxidant. Model compounds have been applied to mimic the reactivity of these enzymes, however, so far the oxidation/oxygenation reactions mainly were performed in organic solvents. For applications in industry there is the danger of the formation of explosive mixtures of organic solvents and dioxygen, that can lead to a fire or even an explosion. In this project copper complexes should be modified in such a way that it will be possible to perform oxidation/oxygenation reactions of organic substrates in water with dioxygen as the sole oxidant.

有机底物（例如E）的选择性氧化。 g。环己烷在化学工业和实验室中非常重要。到目前为止，这些反应中的许多反应都是在有机溶剂中进行的，这些氧化剂通常对基于贵金属的环境和/或昂贵的催化剂有毒或不利。此外，大多数时候有必要在较高的温度和压力下进行这些反应。相比之下，在活性位点，通常用铁或铜离子的单加氧酶能够在水中以氧化剂为氧化剂的二氧化物的环境条件下进行这些反应。模型化合物已用于模拟这些酶的反应性，但是，到目前为止，氧化/氧合反应主要是在有机溶剂中进行的。对于行业的应用，有机溶剂和二氧化物的爆炸性混合物的危险可能导致火灾甚至爆炸。在这个项目中，应以这样的方式对铜复合物进行修饰，以使有机底物在水中以二氧化物作为唯一的氧化剂进行氧化/氧合反应。