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Basic Research of carcinogenesis and cancer prevention (carcinogenesis)

癌变与癌症预防的基础研究（癌变）

基本信息

批准号：
06280110
负责人：
ITO Yoshiaki
金额：
$ 44.16万
依托单位：
Institute for Virus Research, Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1999
项目状态：
已结题

项目摘要

We found that dysregulation or breakdown of cell cycle regulation and so-called DNA transactions, such as DNA replication, repair and recombination, contribute to the genome instability in several specific areas. Since the discovery of oncogenes, it is a common belief that dysregnlation of transcription is also a basis of oncogenesis. A large body of transcription-related results have been accumulated showing a large number of molecules required for transcriptional regulation by forming a large protein complexes, assembly and remodeling of chromatin, histone acetylation and deacetylation by researchers in this research organization. Eleven most significant research accomplishments made in the past 6 ycars are listed below :1. Identification of the genes responsible for Nijmegen syndrome, xeroderma pigmentosus type V and related frame shift mutator.2. Identification of the roles of the Runt domain transcription factor PEBP2 in hematopoiesis, leukemogenesis and osteogenesis.3. Involvement of EVB in gastric cancer.4. Identification of Tsc-2 responsible for familial cancer of rat kidney.5. Induction of liver cancer in transgenic mouse expressing HCV core gene.6. Oncogenes ski and sno also act as tumor suppressors.7. Development of a new gene trap method.8. Identification of receptors for prostanoid involved in colon cancer.9. Establishment of standard for risk assessment for environmental carcinogenesis.10. Identification of the cell type of those involved in Cajal mesenteric tumors.11. Significant advancement in epidemiology.

我们发现，细胞周期调控的失调或破坏以及所谓的DNA交易，如DNA复制，修复和重组，导致了几个特定区域的基因组不稳定性。自癌基因发现以来，人们普遍认为转录调控异常也是肿瘤发生的基础。该研究机构的研究人员积累了大量的转录相关结果，显示转录调控所需的大量分子通过形成大的蛋白质复合物、染色质的组装和重塑、组蛋白乙酰化和去乙酰化。在过去的6年中，取得了以下11项最重要的研究成果：1。Nijmegen综合征、着色性干皮病V型及相关移码突变基因的鉴定.鉴定Runt结构域转录因子PEBP 2在造血、白血病发生和成骨中的作用. EVB与胃癌的关系Tsc-2与大鼠肾癌家族性发病相关性的鉴定. HCV核心基因转基因小鼠肝癌的诱导.癌基因ski和sno也作为肿瘤抑制剂。一种新的基因诱捕方法的开发.结肠癌中前列腺素受体的鉴定。环境致癌风险评价标准的建立.鉴定那些参与卡哈尔肠系膜肿瘤的细胞类型。11.流行病学的重大进步。