Basic Research of carcinogenesis and cancer prevention (carcinogenesis)

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We found that dysregulation or breakdown of cell cycle regulation and so-called DNA transactions, such as DNA replication, repair and recombination, contribute to the genome instability in several specific areas. Since the discovery of oncogenes, it is a common belief that dysregnlation of transcription is also a basis of oncogenesis. A large body of transcription-related results have been accumulated showing a large number of molecules required for transcriptional regulation by forming a large protein complexes, assembly and remodeling of chromatin, histone acetylation and deacetylation by researchers in this research organization. Eleven most significant research accomplishments made in the past 6 ycars are listed below :1. Identification of the genes responsible for Nijmegen syndrome, xeroderma pigmentosus type V and related frame shift mutator.2. Identification of the roles of the Runt domain transcription factor PEBP2 in hematopoiesis, leukemogenesis and osteogenesis.3. Involvement of EVB in gastric cancer.4. Identification of Tsc-2 responsible for familial cancer of rat kidney.5. Induction of liver cancer in transgenic mouse expressing HCV core gene.6. Oncogenes ski and sno also act as tumor suppressors.7. Development of a new gene trap method.8. Identification of receptors for prostanoid involved in colon cancer.9. Establishment of standard for risk assessment for environmental carcinogenesis.10. Identification of the cell type of those involved in Cajal mesenteric tumors.11. Significant advancement in epidemiology.