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Analysis of the mechanism of anti-diabetic effect by the isothiocyanate contained in brassica vegetables.

Analysis of the mechanism of anti-diabetic effect by the isothiocyanate contained in brassica vegetables.
芸苔类蔬菜中异硫氰酸酯抗糖尿病作用机制分析
批准号:
22580125
负责人:
ITO Yoshiaki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
In this study, we investigated the mechanism of the antidiabetic effect of the isothiocyanate in brassica family vegetables. In mouse 3T3-L1 adipocytes, addition of isothiocyanate inhibits the fat accumulation and protects from the insulin resistance induced by oxidative stress. Moreover, the intake of the Japanese horseradish powder which removed the pungent and major isothiocyanate, allyl isothiocyanate, alleviated hyperglycemia in diabetic KK-Ay mice. The similar effect was also observed in diabetic mice fed a diet with another isothiocyanate in watercress. These results suggest a possibility that several isothiocyanates and food stuffs containing isothiocyanates have anti-diabetic effect.
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会议论文
フェネチルイソチオシアネートの糖尿病への効果
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DOI: --
发表时间: 2013
期刊:
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作者: [小野弥奈, 伊藤芳明, 長澤孝志]
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作者: [宇部紗織, 三浦靖, 伊藤芳明]
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沢わさびの抗生活習慣病特性
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发表时间: 2011
期刊: New Food Industry
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作者: [伊藤芳明, 渡部達也, 吉田潤, 木村賢一, 長澤孝志]
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Glycogen synthase kinase-3β inhibition of 6-(methylsulfinyl) hexyl isothi ocyanate derived from wasabi (Wasabia japonica Matsum).
糖原合成酶激酶 3β 对源自芥末 (Wasabia japonica Matsum) 的 6-(甲基亚磺酰基)己基异硫氰酸酯的抑制。
DOI: --
发表时间: 2011
期刊: Biosci.Biotechnol. Biochem.
影响因子: --
作者: [Yoshida J, Nomura S, Nishizaw a N, Ito Y, Kimura K]
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