Coordination Funds

协调基金

• 批准号: 495573943
• 负责人: Professor Dr. Ingo Marzi
• 金额: --
• 依托单位: Klinik für Unfall-, Hand- und Wiederherstellungschirurgie
• 依托单位国家: 德国
• 项目类别: Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/495573943?language=en
• 关键词: Coordination; Funds

Trauma remains a significant cause of morbidity and mortality, particularly in young populations. Despite all advances in research and therapy, it is still not possible to fully explain or predict the clinical course after trauma. To decipher the complex post-traumatic immune and regenerative response, elaborate studies are necessary, requiring close, multicenter collaboration among the participating institutes. This research network between five major trauma centers in Germany (Universities of Frankfurt, Ulm, Aachen, Magdeburg, Erlangen) has emerged from successful joint collaboration in establishing a nationwide biobank for serum/plasma samples from polytrauma patients within the Netzwerk Trauma Forschung (NTF). The network comprises the central project (CP) with the NTF Trauma Bio- and Databank, which is linked to the trauma registry of the DGU, and eight subprojects in a translational approach. The aim is to identify novel mechanisms, potential biomarkers, and treatment strategies and subsequently to test the validity of the newly identified parameters for routine detection in post-traumatic care and rehabilitation using samples from the NTF-Bio- and Databank. This will be reached by combining different experimental approaches, partly using common methodological platforms. The central project (CP) will operate and expand with the NTF biobank and Serum Databank Module of the Trauma Registry and provide clinical data and sample materials to the subprojects. Project F-C involves the development and establishment of a trauma patient extracellular vesicle (EV) biobank and which will be integrated into the CP. Subproject MF-1 will focus on understanding the genetic, molecular, and physiological responses to alcohol exposure in polytrauma that may shift the "balance" of an adaptive response to a pathological response. Subproject F-2 will focus on identifying TBI-specific miRNAs patterns that may aid in the clinical assessment of TBI in polytrauma. Subproject E-1 will focus on understanding the diagnostic and therapeutic potential of microRNAs in relation to cardiac injury after polytrauma. Subproject A-1 is investigating the role of EVs in post-traumatic disorders in cellular and organic cross talk. Subproject A-2 analyzes the role of heparanase, heparan sulfate fragments, and MIF family proteins as diagnostic/therapeutic targets in trauma-induced multi-organ failure. Subproject U-1 will investigate the role of proteases in intestinal innate immunity after experimental and clinical polytrauma and their role in post-traumatic coagulopathy and MODS. The subject of subproject U-2 is the role of age on outcome after combined TBI and hemorrhagic shock. The experimental data from the subprojects in combination with the clinical and experimental data from the NTF Trauma Bio- and Databank will provide a comprehensive, holistic view of the regulatory processes after polytrauma, leading to new insights for individualized patient care and therapy.

创伤仍然是发病率和死亡率的一个重要原因，特别是在年轻人中。尽管在研究和治疗方面取得了所有进展，但仍然不可能完全解释或预测创伤后的临床过程。为了解释复杂的创伤后免疫和再生反应，需要进行详细的研究，需要参与机构之间密切的多中心合作。德国五个主要创伤中心（法兰克福大学、乌尔姆大学、亚琛大学、马格德堡大学、埃尔兰根大学）之间的研究网络是在Netzwerk Trauma Forschung（NTF）内成功联合合作建立的多发性创伤患者血清/血浆样本全国生物库。该网络包括与国家创伤基金创伤生物和数据库相连的中央项目（CP），该项目与DGU的创伤登记处相连，以及采用转化方法的八个子项目。其目的是确定新的机制，潜在的生物标志物和治疗策略，并随后使用NTF-Bio- and Databank的样本测试新确定的创伤后护理和康复常规检测参数的有效性。这将通过结合不同的实验方法，部分使用共同的方法平台来实现。中心项目（CP）将与创伤登记处的NTF生物库和血清数据库模块一起运行和扩展，并为子项目提供临床数据和样本材料。项目F-C涉及开发和建立创伤患者细胞外囊泡（EV）生物库，并将其整合到CP中。子项目MF-1将侧重于了解多发性创伤中酒精暴露的遗传、分子和生理反应，这些反应可能会改变适应性反应与病理反应的“平衡”。子项目F-2将集中于识别TBI特异性miRNA模式，这可能有助于多发性创伤中TBI的临床评估。子项目E-1将侧重于了解microRNA与多发性创伤后心脏损伤相关的诊断和治疗潜力。子项目A-1正在研究EV在细胞和器官串扰中的创伤后障碍中的作用。子项目A-2分析了乙酰肝素酶、硫酸乙酰肝素片段和MIF家族蛋白作为创伤诱导的多器官衰竭的诊断/治疗靶点的作用。子项目U-1将研究蛋白酶在实验性和临床多发性创伤后肠道天然免疫中的作用，以及它们在创伤后凝血功能障碍和MODS中的作用。子项目U-2的主题是年龄对TBI合并失血性休克后结局的作用。来自子项目的实验数据与来自NTF创伤生物和数据库的临床和实验数据相结合，将为多发性创伤后的监管过程提供全面，整体的观点，从而为个性化患者护理和治疗提供新的见解。