Molecular Science on the Specific Roles of Metal Ions in Biological Functions.
金属离子在生物功能中特定作用的分子科学。
基本信息
- 批准号:08249105
- 负责人:
- 金额:$ 27.58万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas
- 财政年份:1996
- 资助国家:日本
- 起止时间:1996 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The project members consisted of four teams focused on investigations of energy conversion, material transformation, signal transduction, and gene expression. Members were encouraged to participate in various kinds of collaborative networks of researchers having different expertise in physical chemistry, coordination chemistry, biochemistry, and molecular biology. Eleven major topics were extensively studied by the four teams including energy conversion in photosynthesis and respiration, activation mechanisms of small molecules by biometals, signal initiation, transduction and reception by metalloproteins, and regulation of gene expression by biometallic compounds. Each of the four teams consisted of the several core members, who were selected by the committee of leaders of the four teams, and the recruited members, who were selected from general applicants by a committee of the Ministry of Education, Science, Sports, and Culture. The total numbers of members were 67, 57, 58, and 50 for the 1^<st>, 2^<nd>, 3^<rd>, and 4^<th> years. The number and composition of members were changed every year. All members were requested to present new results as posters in a two-day open workshop once a year, to which a few distinguished foreign bioinorganic chemists were invited to evaluate the results and to deliver a lecture. The activity has been summarized as SBIC News in J.Biol.Inorg.Chem. 5, 410-415 (2000). The rich accomplishments of individual members are published as focused reviews and original papers in a special issue of J.Inorg.Biochem. 82, #1-4 (2000).
项目成员由四个团队组成,专注于能量转换、材料转换、信号转导和基因表达的研究。鼓励成员参加在物理化学、配位化学、生物化学和分子生物学方面具有不同专长的研究人员的各种合作网络。四个团队广泛研究了11个主要课题,包括光合作用和呼吸作用中的能量转换,生物金属激活小分子的机制,金属蛋白的信号启动、转导和接收,以及生物金属化合物对基因表达的调控。四支队伍中的每支队伍都由四支队伍的领导委员会选出的几名核心成员和由文部科学、体育和文化部的一个委员会从一般申请者中挑选出来的招募成员组成。第一年、第二年、第三年和第四年的会员总数分别为67人、57人、58人和50人。成员的数量和组成每年都会发生变化。所有成员被要求在每年一次为期两天的开放研讨会上以海报的形式展示新成果,邀请几位著名的外国生物无机化学家对结果进行评估并发表演讲。这项活动已被总结为SBIC新闻在J.Biol.Inorg.Chem.5,410-415(2000)。个别成员的丰硕成果以焦点评论和原创论文的形式发表在《生物化学》特刊上。82,#1-4(2000)。
项目成果
期刊论文数量(35)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
T. Iwase et al.: "Infrared evidence for Cu_B ligation of photodissoclated CO of cytochrome c oxidase at ambient temperatures and accompanied deprotonation of a carboxyl side chain of protein"Journal of American Chemical Society. 121. 1415-1416 (1999)
T. Iwase 等人:“细胞色素 c 氧化酶光解 CO 在环境温度下进行 Cu_B 连接并伴随蛋白质羧基侧链去质子化的红外证据”美国化学会杂志。
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- 影响因子:0
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- 通讯作者:
T.Kitagawa et al.: "Time-resolved resonance Raman study of dioxygen reduction by cytochrome c oxidase","Oxygen Homeostasis and its Dynamics"(Y.Ishimura,H.Shimada,and M.Suematsu eds.)" Springer-Verlag.Tokyo. 57-71 (1998)
T.Kitakawa 等人:“细胞色素 c 氧化酶还原双氧的时间分辨共振拉曼研究”,“氧稳态及其动力学”(Y.Ishimura、H.Shimada 和 M.Suematsu 编辑)”Springer-Verlag
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T.Nishino et al.: "Conversion of the dehydrogenase type to the oxidase type of rat liver xanthine dehydrogenase by modification of cysteine residues with fluorodinitrobenzene." J.Biol.Chem.272. 29859-29864 (1997)
T.Nishino 等人:“通过用氟二硝基苯修饰半胱氨酸残基,将大鼠肝脏黄嘌呤脱氢酶的脱氢酶类型转化为氧化酶类型。”
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- 影响因子:0
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S.Ozaki, et al.: "Conversion of Myoglobin into a Peroxygenase : A Catalytic Intermediate of Sulfoxidation by the F43H/H64L Mutant" Journal of the American Chemical Society. 119. 6666-6667 (1997)
S.Ozaki 等人:“肌红蛋白转化为过氧合酶:F43H/H64L 突变体磺化氧化的催化中间体”美国化学会杂志。
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- 影响因子:0
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E.Kimura et al.: "Dynamic Enolate Recognition in Aqueous Solution by Zinc (II) in a Phenacyl-Pendant Cycle Complex : Implications for the Role of Zinc (II) in Class II Aldolases."Journal of American Chemical Society. 121. 1267-1274 (1999)
E.Kimura 等人:“苯甲酰基-悬垂循环复合物中的锌 (II) 在水溶液中的动态烯醇化物识别:对锌 (II) 在 II 类醛缩酶中的作用的影响。”美国化学会杂志。
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KITAGAWA Teizo其他文献
KITAGAWA Teizo的其他文献
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{{ truncateString('KITAGAWA Teizo', 18)}}的其他基金
UV resonance Raman investigation on detection of higher order structural changes of heme proteins and elucidation of functional regulation mechanism
紫外共振拉曼研究检测血红素蛋白高阶结构变化并阐明功能调节机制
- 批准号:
24350086 - 财政年份:2012
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Structural Chemistry on Information Transduction through Allosteric Effects in Heme Proteins
通过血红素蛋白变构效应进行信息转导的结构化学
- 批准号:
21350098 - 财政年份:2009
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Structural Chemistry Involved in Discrimination of Diatomic Ligands and Transduction Mechanism of Sensed Information of Gas Sensing Heme Proteins
双原子配体识别的结构化学及气敏血红素蛋白传感信息的转导机制
- 批准号:
19350089 - 财政年份:2007
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of Detection Methods of Dynamical Higher Order Structures of Proteins and Its Application to Elucidation of Structure-Function Relations of Proteins.
蛋白质动态高阶结构检测方法的发展及其在阐明蛋白质结构功能关系中的应用。
- 批准号:
14001004 - 财政年份:2002
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Specially Promoted Research
Time-Resolved Vibrational Spectroscopic Investigation of Ultrafast Protein Dynamics Coupled with Photoreaction
超快蛋白质动力学与光反应耦合的时间分辨振动光谱研究
- 批准号:
12045264 - 财政年份:2000
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Time-Resolved Vibrational Spectroscopic Study of Higher Order Structural Changes of Protein Induced by Nanosecond Temperature Jump.
纳秒温度跳跃引起的蛋白质高阶结构变化的时间分辨振动光谱研究。
- 批准号:
10480187 - 财政年份:1998
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Elucidation of Reaction Mechanisms of Biological Nitric Oxide by Vibrational Spectroscopy
振动光谱法阐明生物一氧化氮的反应机制
- 批准号:
07454157 - 财政年份:1995
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Detection of Fast Conformation Changes of Proteins by Time-Resolved Resonance Raman Spectroscopy
通过时间分辨共振拉曼光谱检测蛋白质的快速构象变化
- 批准号:
05453212 - 财政年份:1993
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Molecular Science for Elucidation of Proton Active Transport and Electron Transfers through Proteins.
通过蛋白质阐明质子主动传输和电子转移的分子科学。
- 批准号:
02453157 - 财政年份:1990
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Quantum Theory and Spectroscopy of Proteins as Biomachines
作为生物机器的蛋白质的量子理论和光谱学
- 批准号:
02305013 - 财政年份:1990
- 资助金额:
$ 27.58万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)