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Molecular Science on the Specific Roles of Metal Ions in Biological Functions.

金属离子在生物功能中特定作用的分子科学。

基本信息

批准号：
08249105
负责人：
KITAGAWA Teizo
金额：
$ 27.58万
依托单位：
Okazaki National Research Institutes
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 2000
项目状态：
已结题

项目摘要

The project members consisted of four teams focused on investigations of energy conversion, material transformation, signal transduction, and gene expression. Members were encouraged to participate in various kinds of collaborative networks of researchers having different expertise in physical chemistry, coordination chemistry, biochemistry, and molecular biology. Eleven major topics were extensively studied by the four teams including energy conversion in photosynthesis and respiration, activation mechanisms of small molecules by biometals, signal initiation, transduction and reception by metalloproteins, and regulation of gene expression by biometallic compounds. Each of the four teams consisted of the several core members, who were selected by the committee of leaders of the four teams, and the recruited members, who were selected from general applicants by a committee of the Ministry of Education, Science, Sports, and Culture. The total numbers of members were 67, 57, 58, and 50 for the 1^<st>, 2^<nd>, 3^<rd>, and 4^<th> years. The number and composition of members were changed every year. All members were requested to present new results as posters in a two-day open workshop once a year, to which a few distinguished foreign bioinorganic chemists were invited to evaluate the results and to deliver a lecture. The activity has been summarized as SBIC News in J.Biol.Inorg.Chem. 5, 410-415 (2000). The rich accomplishments of individual members are published as focused reviews and original papers in a special issue of J.Inorg.Biochem. 82, #1-4 (2000).

项目成员由四个团队组成，专注于能量转换、材料转换、信号转导和基因表达的研究。鼓励成员参加在物理化学、配位化学、生物化学和分子生物学方面具有不同专长的研究人员的各种合作网络。四个团队广泛研究了11个主要课题，包括光合作用和呼吸作用中的能量转换，生物金属激活小分子的机制，金属蛋白的信号启动、转导和接收，以及生物金属化合物对基因表达的调控。四支队伍中的每支队伍都由四支队伍的领导委员会选出的几名核心成员和由文部科学、体育和文化部的一个委员会从一般申请者中挑选出来的招募成员组成。第一年、第二年、第三年和第四年的会员总数分别为67人、57人、58人和50人。成员的数量和组成每年都会发生变化。所有成员被要求在每年一次为期两天的开放研讨会上以海报的形式展示新成果，邀请几位著名的外国生物无机化学家对结果进行评估并发表演讲。这项活动已被总结为SBIC新闻在J.Biol.Inorg.Chem.5,410-415(2000)。个别成员的丰硕成果以焦点评论和原创论文的形式发表在《生物化学》特刊上。82，#1-4(2000)。