Molecular Science on the Specific Roles of Metal Ions in Biological Functions.

项目成员由四个团队组成，专注于能量转换，物质转化，信号转导和基因表达的研究。鼓励成员参加在物理化学、配位化学、生物化学和分子生物学方面具有不同专长的研究人员的各种合作网络。四个研究小组对11个主要课题进行了广泛的研究，包括光合作用和呼吸的能量转换，生物金属对小分子的激活机制，金属蛋白的信号启动、转导和接收，以及生物金属化合物对基因表达的调控。四个小组中的每一个小组都由四个小组的领导委员会选出的几名核心成员和教育、科学、体育和文化部的一个委员会从普通申请者中选出的招募成员组成。第1年、第2年、第3年和第4年的成员总数分别为67人、57人、58人和50<st><nd><rd><th>人。成员的人数和组成每年都有变化。所有成员被要求在每年一次的为期两天的公开研讨会上以海报的形式展示新的成果，邀请一些杰出的外国生物无机化学家来评估结果并发表演讲。该活性已在J.Biol.Inorg.Chem. 5，410-415（2000）中总结为SBIC News。个别成员的丰富成就作为重点评论和原创论文发表在J.Inorg.Biochem. 82，#1-4（2000）的特刊上。

The project members consisted of four teams focused on investigations of energy conversion, material transformation, signal transduction, and gene expression. Members were encouraged to participate in various kinds of collaborative networks of researchers having different expertise in physical chemistry, coordination chemistry, biochemistry, and molecular biology. Eleven major topics were extensively studied by the four teams including energy conversion in photosynthesis and respiration, activation mechanisms of small molecules by biometals, signal initiation, transduction and reception by metalloproteins, and regulation of gene expression by biometallic compounds. Each of the four teams consisted of the several core members, who were selected by the committee of leaders of the four teams, and the recruited members, who were selected from general applicants by a committee of the Ministry of Education, Science, Sports, and Culture. The total numbers of members were 67, 57, 58, and 50 for the 1^<st>, 2^<nd>, 3^<rd>, and 4^<th> years. The number and composition of members were changed every year. All members were requested to present new results as posters in a two-day open workshop once a year, to which a few distinguished foreign bioinorganic chemists were invited to evaluate the results and to deliver a lecture. The activity has been summarized as SBIC News in J.Biol.Inorg.Chem. 5, 410-415 (2000). The rich accomplishments of individual members are published as focused reviews and original papers in a special issue of J.Inorg.Biochem. 82, #1-4 (2000).