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Structural Chemistry on Information Transduction through Allosteric Effects in Heme Proteins

Structural Chemistry on Information Transduction through Allosteric Effects in Heme Proteins
通过血红素蛋白变构效应进行信息转导的结构化学
批准号：
21350098
负责人：
KITAGAWA Teizo
金额：
$12.15万
依托单位：
University of Hyogo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21350098/
关键词：
生物無機化学振動分光学アロステリック効果ガスセンサー蛋白ヘモグロビン情報伝達生体分子化学生物物理共鳴ラマンヘム蛋白質紫外共鳴ラマン生体生命情報学生体分子科学紫外共鳴ラマン散乱

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中文摘要
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英文摘要
Structural chemistry involved in allosteric effects of heme proteins was investigated with visible and ultraviolet resonance Raman spectroscopy. About hemoglobin as a fundamental molecule, a quaternary structure of half-ligated state was quantitatively determined on the basis of inter-subunit interactions. As applications, information transduction pathway and its dynamics were elucidated with two oxygen sensor proteins, DOS and HemAT, and structural effects of effector binding was revelaed for an NO sensor protein, sGC. For respiration enzyme, proton pumping mechanism of a mammalian cytochrome c oxidase was examined.
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T-quaternary structure of oxy human adult hemoglobin in the presence of two allosteric effectors, L35 and IHP.
存在两种变构效应子 L35 和 IHP 时含氧成人血红蛋白的 T-四级结构。
DOI： --
发表时间： 2011
期刊： Biochim Biophys Acta.
影响因子： --
作者： [Kanaori K, Tajiri Y, Tsuneshige A, Ishigami I, Ogura T, Tajima K, Neya S, Yonetani T.]
通讯作者： Yonetani T.
Structural analysis of FMN and iron-sulfur clusters of bovine heart NADH-ubiquinone oxidoreductase by resonance Raman spectroscopy
共振拉曼光谱法分析 FMN 和牛心 NADH-泛醌氧化还原酶铁硫簇的结构
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Masahide Hikita, et al.]
通讯作者： et al.
Protein Dynamics of Cytochrome c Oxidawith se upon CN-Photolysis as studied with Resonance Raman Spectroscopy
用共振拉曼光谱研究 CN 光解后细胞色素 c 氧化的蛋白质动力学
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Takeshi Nishigaki, et al.]
通讯作者： et al.
Ultraviolet time-resolved resonance Raman investigation of structural dynamics of Hem-AT-Bs following CO photodissociation
CO 光解离后 Hem-AT-B 结构动力学的紫外时间分辨共振拉曼研究
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Kitagawa, T]
通讯作者： T
共 105 条
    UV resonance Raman investigation on detection of higher order structural changes of heme proteins and elucidation of functional regulation mechanism
    • 批准号：
      24350086
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $11.73万
    • 财政年份：
      2012
    • 负责人：
      KITAGAWA Teizo
    • 依托单位：
      University of Hyogo
    Structural Chemistry Involved in Discrimination of Diatomic Ligands and Transduction Mechanism of Sensed Information of Gas Sensing Heme Proteins
    Development of Detection Methods of Dynamical Higher Order Structures of Proteins and Its Application to Elucidation of Structure-Function Relations of Proteins.
    Time-Resolved Vibrational Spectroscopic Investigation of Ultrafast Protein Dynamics Coupled with Photoreaction
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