Structural insights into the complex interplay between latrotoxin and the cell adhesion receptors neurexin and latrophilin (A15*)

点击翻译按钮获取中文摘要

The cell adhesion GPCR latrophilin 1 (LPHN1) and neurexins (NRXNs) were discovered as α-latrotoxin (α-LTX) receptors. Both receptors interact with high affinity and presumably form an intercellular adhesion complex. Interaction of the toxin with these receptors induces a conformational change and the insertion of the toxin into the presynaptic membrane, which forms a cation-selective pore that subsequently leads to the degeneration of the synapse. We aim to gain mechanistic insights into the interplay between NRXN, LPHN1 and LTX through structural analyses.