Structural insights into the complex interplay between latrotoxin and the cell adhesion receptors neurexin and latrophilin (A15*)

细胞粘附GPCR发现嗜latrophilin 1 （LPHN1）和神经毒素（NRXNs）为α-latrotoxin （α-LTX）受体。两种受体相互作用具有高亲和力，并可能形成细胞间粘附复合物。毒素与这些受体的相互作用引起构象变化，并将毒素插入突触前膜，形成一个阳离子选择性孔，随后导致突触退化。我们的目标是通过结构分析获得NRXN， LPHN1和LTX之间相互作用的机制见解。

The cell adhesion GPCR latrophilin 1 (LPHN1) and neurexins (NRXNs) were discovered as α-latrotoxin (α-LTX) receptors. Both receptors interact with high affinity and presumably form an intercellular adhesion complex. Interaction of the toxin with these receptors induces a conformational change and the insertion of the toxin into the presynaptic membrane, which forms a cation-selective pore that subsequently leads to the degeneration of the synapse. We aim to gain mechanistic insights into the interplay between NRXN, LPHN1 and LTX through structural analyses.