Structural insights into the complex interplay between latrotoxin and the cell adhesion receptors neurexin and latrophilin (A15*)

对河豚毒素与细胞粘附受体神经毒素和河豚毒素 (A15*) 之间复杂相互作用的结构见解

• 批准号: 496760974
• 金额: --
• 依托单位: Center for Soft Nanoscience (SoN)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/496760974?language=en
• 关键词: Structural; insights; into; complex; interplay

The cell adhesion GPCR latrophilin 1 (LPHN1) and neurexins (NRXNs) were discovered as α-latrotoxin (α-LTX) receptors. Both receptors interact with high affinity and presumably form an intercellular adhesion complex. Interaction of the toxin with these receptors induces a conformational change and the insertion of the toxin into the presynaptic membrane, which forms a cation-selective pore that subsequently leads to the degeneration of the synapse. We aim to gain mechanistic insights into the interplay between NRXN, LPHN1 and LTX through structural analyses.

细胞黏附分子LPHN1和NRXNS被发现为α-LTX受体。这两种受体都以高亲和力相互作用，并可能形成细胞间黏附复合体。毒素与这些受体的相互作用导致构象改变，并将毒素插入突触前膜，形成阳离子选择孔，从而导致突触变性。我们的目标是通过结构分析从机制上深入了解NRXN、LPHN1和LTX之间的相互作用。