Synthesis and Host-Guest Chemistry of Organically-Functionalized Polyoxomolybdate Wheels

有机功能化多钼酸盐轮的合成和主客体化学

• 批准号: 496875799
• 负责人: Professor Ulrich Kortz, Ph.D.
• 金额: --
• 依托单位: Department of Life Sciences and Chemistry
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/496875799?language=en
• 关键词: Synthesis; Host; Guest; Chemistry; Organically

Host–guest encapsulation processes in chemistry assisted by supramolecular interactions are of importance in drug delivery, separation processes and sensing applications. Polyoxometalates (POMs) are discrete, anionic metal-oxo clusters and attractive for host-guest chemistry because of the ease of controlling their molecular properties, such as size, shape, composition, charge, acidity, redox potential and solubility in aqueous and organic media. POMs have been shown to be highly effective as antiviral, antitumor, antibacterial, and antidiabetic agents both in vitro and in vivo. Very large, discrete wheel- or ball-shaped polyoxomolybdates (e.g. {Mo154} wheel, {Mo132} ball) have been known for >20 years, and some limited insight has been obtained on their role as hosts for guest encapsulation. However, systematic studies on guest uptake and release all the way to drug delivery applications using discrete POM wheels as hosts are largely unexplored. The first key aim of this project is to design and synthesize discrete, organically-functionalized molybdenum-oxo wheels and utilize them for bio-medical applications via host-guest interactions, in analogy to organic hosts such as crown ethers, cyclodextrins, calixarenes and cucurbiturils. We will also explore their sensing behaviour for various thiol contaminants and nitro-explosives, as well as their catalytic activities in reactions, such as the oxidation of organic sulfides and epoxidation of olefins. The second key aim of this project is the construction of POM-wheel-based extended, porous framework materials known as metal-organic frameworks (MOFs), using individual POMs as secondary building units. This represents a promising strategy for generating POM-based MOF materials, which merge the merits of both POMs and MOFs, and hence give rise to highly attractive, host-guest based properties in areas such as proton conduction, catalysis and bio-medicine. This project hence deals with a completely new research field, which is likely to result in the discovery of promising multi-functional materials with the potential for clinical and/or industrial applications.

化学中由超分子相互作用辅助的主客体封装过程在药物输送、分离过程和传感应用中非常重要。多金属氧酸盐 (POM) 是离散的阴离子金属氧簇，由于易于控制其分子特性，如尺寸、形状、组成、电荷、酸度、氧化还原电位以及在水和有机介质中的溶解度，因此对主客体化学具有吸引力。 POM 在体外和体内均已被证明作为抗病毒、抗肿瘤、抗菌和抗糖尿病药物非常有效。非常大的、离散的轮状或球形多钼酸盐（例如{Mo154}轮、{Mo132}球）已知超过20年，并且对其作为客体封装的主体的作用获得了一些有限的了解。然而，使用离散 POM 轮作为主体对客体吸收和释放一直到药物输送应用的系统研究在很大程度上尚未探索。该项目的第一个关键目标是设计和合成离散的有机功能化钼氧轮，并通过主客体相互作用将其用于生物医学应用，类似于冠醚、环糊精、杯芳烃和葫芦脲等有机主体。我们还将探索它们对各种硫醇污染物和硝基爆炸物的传感行为，以及它们在反应中的催化活性，例如有机硫化物的氧化和烯烃的环氧化。该项目的第二个关键目标是使用单个 POM 作为辅助建筑单元，构建基于 POM 轮的扩展多孔框架材料，称为金属有机框架 (MOF)。这代表了一种有前途的生产基于 POM 的 MOF 材料的策略，它融合了 POM 和 MOF 的优点，因此在质子传导、催化和生物医学等领域产生了极具吸引力的、基于主客体的特性。因此，该项目涉及一个全新的研究领域，这可能会导致发现具有临床和/或工业应用潜力的有前途的多功能材料。