Microscope for high-throughput and screening

用于高通量和筛选的显微镜

• 批准号: 497512124
• 金额: --
• 依托单位: Universität zu Lübeck
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2022
• 资助国家: 德国
• 起止时间: 2021-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/497512124?language=en
• 关键词: Microscope; throughput; screening

application is made for an automated live imaging system for the analysis of fluorescence signals in living cell and tissue cultures under controlled and programmable environmental conditions, some of which are rhythmic. The device will be used to record longitudinal measurements of molecular and physiological rhythms with the aid of fluorescence microscopy at the single cell level and in a network over several days and to analyze their circadian rhythms. The aim is to characterize the ontogenetic and organ-specific development and stabilization of circadian rhythms and molecular manipulation mechanisms as a potential therapeutic approach for neuropsychiatric and metabolic-endocrine diseases.

该应用程序用于自动实时成像系统，用于在受控和可编程的环境条件下分析活细胞和组织培养物中的荧光信号，其中一些环境条件是有节奏的。该设备将用于借助荧光显微镜在单细胞水平和网络中记录数天的分子和生理节律的纵向测量，并分析其昼夜节律。目的是表征昼夜节律和分子操纵机制的个体发生和器官特异性发育和稳定，作为神经精神和代谢内分泌疾病的潜在治疗方法。