Maintenance of profound deaf model mouse and functional analysis of it's auditory system
深聋模型小鼠的维护及其听觉系统功能分析
基本信息
- 批准号:13035045
- 负责人:
- 金额:$ 2.82万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We isolated a spontaneous mutant animal with abnormal behaviors when we encountered epileptic mice exhibiting circling movement in our closed colony of ICR Ascites mice. The mutant mice, designated to kuru2, did not respond to sounds. In order to elucidate their hearing ability, we measured the auditory brain stem response (ABR) of the mice. ABR demonstrated that the mice were profoundly impaired acuity. Abnormal behaviors including circling, ataxic gait, and hyperirritability of the mouse were demonstrated.The genetic mode of the mouse was autosomal recessive. This result came from an exploration of the pedigree and backcross examinations. Either male or female mutants were mated with wild type animals. The F1 mice were backcrossed to the mutant mice. Behavior of 100 offspring were analyzed. None of the offspring F1 demonstrated hearing impairment or abnormal behaviors. Normal versus deaf mice was one to one. The result was same in the both sexes. We presumed that the phenotype might be from a single gene mutation. Since the animal has a wide variety of symptoms, a large-scale study will be required to elucidate the underlying genetics.
当我们在我们封闭的ICR腹水小鼠群中遇到表现出盘旋运动的癫痫小鼠时,我们分离出一种自发突变的行为异常的动物。被命名为kuru2的突变小鼠对声音没有反应。为了阐明其听力能力,我们测量了小鼠的听觉脑干反应(ABR)。ABR表明小鼠的敏锐度严重受损。该小鼠表现出绕圈、共济失调步态和过度兴奋等异常行为,其遗传方式为常染色体隐性遗传。这一结果来自于对系谱和回交检验的探索。雄性或雌性突变体均与野生型动物交配。将F1小鼠与突变小鼠回交。对100只子代的行为进行了分析。没有后代F1表现出听力障碍或异常行为。正常和失聪的老鼠是一比一。结果在两性中是相同的。我们推测该表型可能来自单个基因突变。由于该动物具有多种症状,因此需要进行大规模研究来阐明潜在的遗传学。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hasegawa N., Watanabe M., Inoue H., Kobayashi T., Kojima H., Manome Y.: "Mutant ICR mouse, Kuru2, manifests hearing impairment and abnormal behavior"In vivo. 16. 349-360 (2002)
Hasekawa N.、Watanabe M.、Inoue H.、Kobayashi T.、Kojima H.、Manome Y.:“突变 ICR 小鼠 Kuru2 在体内表现出听力障碍和异常行为”。
- DOI:
- 发表时间:
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- 影响因子:0
- 作者:
- 通讯作者:
Hasagawa N., Watanabe M., Inoue H., Kobayashi T., Kojima H. and Manome Y.: "Mutant ICR mouse, Kuru2, manifests hearing impairment and abnormal Behavior"In Vivo. 16. 349-360 (2002)
Hasakawa N.、Watanabe M.、Inoue H.、Kobayashi T.、Kojima H. 和 Manome Y.:“突变 ICR 小鼠 Kuru2 表现出听力障碍和异常行为”体内。
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- 影响因子:0
- 作者:
- 通讯作者:
Hasagawa N., Watanabe M., Inoue H., Kobayashi T., Kojima H., Manome Y.: "Mutant ICR mouse, Kuru2, manifests hearing impairment and abnormal behavior"In vivo. 16. 349-360 (2002)
Hasakawa N.、Watanabe M.、Inoue H.、Kobayashi T.、Kojima H.、Manome Y.:“突变 ICR 小鼠 Kuru2 在体内表现出听力障碍和异常行为”。
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2009 - 期刊:
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Construction of comprehensive sleep support system for transport workers using wearable activity meter
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16K16000 - 财政年份:2016
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$ 2.82万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Contrastive analysis of English and Japanese disfluencies using parallel spontaneous speech corpora of the two languages
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24520494 - 财政年份:2012
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New Challenges for Statistics Education for Lifelong Learning in the Knowledge-based Society
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21300108 - 财政年份:2009
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Grant-in-Aid for Scientific Research (B)
A contrastive study on speech disfluencies in English and Japanese
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21520467 - 财政年份:2009
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A Study on Developing a Curriculum System for Statistics Education According to the International Standard in the Information Age
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17300090 - 财政年份:2005
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14380124 - 财政年份:2002
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