New Chemical Approaches for Functional of DNA/RNA

DNA/RNA 功能的新化学方法

• 批准号: 13132101
• 负责人: KOMIYAMA Makoto
• 金额: $ 11.58万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13132101/
• 关键词: DNA; Artificial Restriction Enzyme; Functional Nucleic Acid; RNA; Peptide Nucleic Acid; Biopolvmer; Proteins; Ribozvme; 加水分解; リボザイム; DNA分組織体; DNA分子組織体; 刺激応答性核酸; バイオテクノロジー; 遺伝子操作; アクリジン

Prof. Aizawa, Prof. Inoue, and Prof. Kunitake estimated this research project, and gave some advices on the management as an assessment committee of this project. Prof. Komiyama endeavored to have the members of this project promote the exchanges of information with one another.As an opportunity to be estimated by assessment committee and to discuss this project, the group meeting was held two times a year, and international meetings were also held at the time. Moreover, news letters and research results were disclosed on the web. Finally, the full report for this project was made and published.

Aizawa教授、Inoue教授和Kuitake教授对本研究项目进行了评估，并对作为本项目评估委员会的管理提出了一些建议。Komiyama教授努力推动这个项目成员之间的信息交流，作为评估委员会评估和讨论这个项目的机会，小组会议每年举行两次，当时还举行了国际会议。此外，新闻信和研究结果也在网上披露。最后，制作并发布了本项目的完整报告。

项目成果

M.Komiyama et al.: "Cutting DNA and RNA""Handbook on the Physics and Chemistry of Rare Earths". 35(印刷中).

M. Komiyama 等人：“切割 DNA 和 RNA”“稀土物理和化学手册”35（印刷中）。

M.Komiyama et al.: "Sequence-Selective Artificial Ribonucleases"Methods in Enzymology, Ribonucleases Part 1. 341. 455-468 (2001)

M.Komiyama 等：“酶学中的序列选择性人工核糖核酸酶”方法，核糖核酸酶第 1. 341. 455-468 部分（2001）

M.Komiyama et al.: "Sequence-selective scission of DNA and RNA by lanthanide ions and their complexe in"Metal Ions in Biological Systems""Marcel Dekker(印刷中).

M. Komiyama 等人：““生物系统中的金属离子”中的镧系离子及其复合物对 DNA 和 RNA 的序列选择性裂解”Marcel Dekker（出版中）。

A.Kuzuya et al.: "New ribozyme-mimics employing Mg (II) ion as catalytic center"Chem. Lett.. 584-585 (2001)

A.Kuzuya 等人：“采用 Mg (II) 离子作为催化中心的新型核酶模拟物”Chem.

A.Kuzuya et al.: "Site-selective artificial ribonuclease using pinpoint RNA activation"Nucleic Acids Res. Supple. 1. 131-132 (2001)

A.Kuzuya 等人：“使用精确 RNA 激活的位点选择性人工核糖核酸酶”核酸研究。