2010/AFGN Collaborative Project: An exemplary calcium signaling network in plant abiotic stress responses

2010/AFGN 合作项目：植物非生物胁迫反应中的典型钙信号网络

• 批准号: 49803633
• 负责人: Professor Dr. Jörg Kudla
• 金额: --
• 依托单位: Department of Plant and Microbial Biology
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/49803633?language=en
• 关键词: 2010; AFGN; Collaborative; Project; exemplary

The proposed project aims to perform a systems analysis of the mechanisms and function of a central calcium-decoding signaling network from Arabidopsis comprising of protein kinases (AtCIPKs), which interact with calcium sensor proteins (AtCBLs). In general, this project is focused on the functional characterization of this elaborate CBL-CIPK interaction network and its contribution to integrate and specifically decode various calcium signals during abiotic stress responses. Consequently this project aims to: (1) explore the functional principles of information processing in this signaling network (2) identify the physiological function and interplay of its components (3) identify and characterize target proteins and processes of this signaling system. This project will generate insights into calcium signaling mechanisms with relevance for all eukaryotes, provide novel tools for protein-interaction analyses in plants and other organisms and knock-out mutant combinations for different areas in plant biology. Finally, this project will shed light on the molecular basis for plant tolerance to environmental stress factors, providing a platform for generating crops with enhanced stress tolerance and agronomic performance.

该项目旨在对拟南芥中由蛋白激酶（AtCIPKs）组成的中央钙解码信号网络的机制和功能进行系统分析，该网络与钙传感器蛋白（AtCBLs）相互作用。总的来说，该项目的重点是这个精心制作的CBL-CIPK相互作用网络的功能特性及其在非生物胁迫响应过程中整合和特异性解码各种钙信号的贡献。因此，本项目旨在：（1）探索该信号网络中信息处理的功能原理（2）确定其组成部分的生理功能和相互作用（3）确定和表征该信号系统的靶蛋白和过程。该项目将深入了解与所有真核生物相关的钙信号传导机制，为植物和其他生物体中的蛋白质相互作用分析提供新的工具，并为植物生物学的不同领域提供敲除突变体组合。最后，该项目将阐明植物对环境胁迫因素耐受性的分子基础，为产生具有增强的胁迫耐受性和农艺性能的作物提供平台。