Immune Surveillance, Its cellular and molecular basis, regulation and maintenance

免疫监视、其细胞和分子基础、调节和维持

• 批准号: 15078101
• 负责人: WATANABE Takeshi
• 金额: $ 39.62万
• 依托单位: RIKEN (2004-2006)Kyushu University (2003)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15078101/
• 关键词: immune surveillance; spatio-temporal regulation; thymus, bone marrow, lymph nodes; recognition and diversity; memory; signal transduction; autoimmune diseases; regeneration,; 胸腺、骨髄、リンパ組織; 危険シグナル; 免疫監視機構; 自然免疫; 認識の多様性; 免疫シグナル; ワクチン; 免疫組織の修復と

The concept of "Immune Surveillance" was first proposed almost 50 years ago as a mechanism for elimination of nascent cancer cells before they develop into clinically evident tumors. However, the fundamental nature of this concept has not yet been fully clarified at either the cellular or molecular level, even though remarkable progress has been made in tumor immunology. Not only in the control of cancer, Immune Surveillance system plays a crucial role in the prevention of severe infection as well as the regulation of autoreactive immune responses. The objective of this special project is to broadly develop the basic research concerning the structural basis of the immune surveillance system in mice and humans, the regulation and maintenance of the surveillance network, and its clinical significance.Year 2006 was the last year of this 4-years-term project on the Immune Surveillance Mechanism. As one of the activities of the "Summation Group (Sokatsu-han)", we especially promoted the interaction between researchers in order to facilitate their research activities on the clarification of the cellular and molecular basis of immune surveillance mechanism as well as invention to repair and reinforcement of the surveillance in our body. During 2006, over 200 papers were published. Among them, 30 papers were published in Journals of IF : over 20, and 60 papers in Journals of IF :10-20. We held the Second International Symposium on the Immune Surveillance at Tokyo on February 14, 15, 2007. We invited 11 foreign speakers from US and Europe who have been extensively developing their research on immune surveillance. It was very successful. During 4 years, 600 papers were published. Among them, 205 papers were reported in the Journals of IF : over 10. Over 50 patents were applied. We held 3 major symposia including 2 international symposia.

“免疫监视”的概念在大约50年前首次提出，作为在新生癌细胞发展成临床明显肿瘤之前消除它们的机制。然而，这一概念的基本性质尚未完全澄清，无论是在细胞或分子水平，即使在肿瘤免疫学取得了显着的进展。免疫监视系统不仅在癌症的控制中，在预防严重感染以及调节自身反应性免疫反应方面也起着至关重要的作用。本研究课题的目的是广泛开展小鼠和人类免疫监视系统的结构基础、监视网络的调节和维持及其临床意义等基础研究。2006年是本研究课题的最后一年。作为“总结小组（Sokatsu-han）”的活动之一，我们特别促进了研究人员之间的互动，以促进他们在阐明免疫监视机制的细胞和分子基础以及修复和加强我们体内监视的发明方面的研究活动。2006年期间，发表了200多篇论文。其中，在IF期刊上发表论文30篇：20篇以上，在IF期刊上发表论文60篇：10-20篇。我们于2007年2月14日、15日在东京举行了第二届免疫监测国际研讨会。我们邀请了11位来自美国和欧洲的外国演讲者，他们一直在广泛开展免疫监视的研究。它非常成功。4年间，共发表论文600篇。其中，205篇论文被IF期刊报道：超过10。申请专利50多项。我们举办了3次大型研讨会，其中包括2次国际研讨会。

项目成果

2型ヒスタミン受容体タンパクに結合し, かつ2型ヒスタミン受容体とヒスタミンの結合を阻止しうるモノクローナル抗体

一种与2型组胺受体蛋白结合的单克隆抗体，可以阻断2型组胺受体与组胺之间的结合。

• 发表时间: 2007

Role of SPA-1 in phenotypes of CML induced by BCR-ABL-expressing hematopoietic progenitors in mouse model.

SPA-1 在小鼠模型中表达 BCR-ABL 的造血祖细胞诱导的 CML 表型中的作用。

• 发表时间: 2006
• 期刊: Cancer Res. 66
• 作者: Kometani;K.;Kawamata;S.;Shinozuka;Y.;Era;T.;Taniwaki;M.;Hattori;M.;Minato;N.
• 通讯作者: N.

Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease

• DOI: 10.4049/jimmunol.173.3.2118
• 发表时间: 2004-08-01
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Fujio, K;Okamoto, A;Yamamoto, K
• 通讯作者: Yamamoto, K

A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities

• DOI: 10.1038/ng1540
• 发表时间: 2005-05-01
• 期刊: NATURE GENETICS
• 影响因子: 30.8
• 作者: Kochi, Y;Yamada, R;Yamamoto, K
• 通讯作者: Yamamoto, K

The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation

• DOI: 10.1182/blood-2005-12-020164
• 发表时间: 2007-01-01
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Suzuki, Jun-ichiro;Yamasaki, Sho;Saito, Takashi
• 通讯作者: Saito, Takashi