Dynamism of immune cells in immune-tissue formation

免疫细胞在免疫组织形成中的动态

• 批准号: 15078203
• 负责人: MATSUSHIMA Kouji
• 金额: $ 64.06万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15078203/
• 关键词: chemokine; dendritic cells; virus; lymph node; migration; CTL; memory; ウイルス; TNF-α; 炎症; 免疫組織; 胸腺; 免疫細胞移動

This project was intended to reveal the regulation of dynamic trafficking of subset of immune cells by chemokines to form immune-tissues in response to pathogen infection. As a result, the following points were found. 1. myeloid dendritic cells (mDCs) capture and process antigens, transport them from the tissue to the draining lymph nodes (LNs) and act as an antigen presenting cells, whereas plasmacytoid DCs (pDCs) directly migrate into inflamed LNs through HEV to help APC function of mDCs 2. nTreg home to the paracortex area of peripheral LNs through HEV in a CCR7 dependent manner and make cluster with subset of DCs 3. a primary response during re-challenge significantly contributes to memory T cell. Upon re-challenge, the skewed Vb usage and T-cell receptor (TCR) repertoire of pre-existing memory T cells is partly corrected by diversity in a newly primed (primary) T cell population. Importantly, this primary population expands more vigorously in a subsequent antigen encounter. These findings indicate that memory T cell populations evolve over multiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primary populations have essential roles in the perpetuation of antigen-specific T cell populations.

该项目旨在揭示通过趋化因子对免疫细胞子集的动态运输的调节，以形成对病原体感染的免疫组织。结果，发现了以下几点。 1. myeloid dendritic cells (mDCs) capture and process antigens, transport them from the tissue to the draining lymph nodes (LNs) and act as an antigen presenting cells, whereas plasmacytoid DCs (pDCs) directly migrate into inflamed LNs through HEV to help APC function of mDCs 2. nTreg home to the paracortex area of​​ peripheral LNs through HEV以CCR7依赖的方式，并用DCS 3的子集使群集成为簇。重新挑战期间的主要响应显着有助于记忆T细胞。重新挑战后，偏斜的VB使用率和T-Cell受体（TCR）曲目的预先存在记忆T细胞部分通过新启动（原发性）T细胞种群的多样性进行了纠正。重要的是，在随后的抗原遭遇中，这种初级人群会更剧烈地扩展。这些发现表明，记忆T细胞种群在多种挑战中演变，有利于最近相遇中产生的记忆T细胞，并表明这些主要种群在抗原特异性T细胞群体的持久性中具有重要作用。

项目成果

Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs.

浆细胞样 DC 帮助淋巴结 DC 诱导抗 HSV CTL。

• DOI: 10.1084/jem.20041961
• 发表时间: 2005-08-01
• 期刊: JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 15.3
• 作者: Yoneyama, H;Matsuno, K;Toda, E;Nishiwaki, T;Matsuo, N;Nakano, A;Narumi, S;Lu, B;Gerard, C;Ishikawa, S;Matsushima, K
• 通讯作者: Matsushima, K

Exacerbation of granuloma formation in interleukin-1 receptor antagonist-deficient mice with impaired cell migration associated with Th2 cytokine production.

在白细胞介素 1 受体拮抗剂缺陷小鼠中，与 Th2 细胞因子产生相关的细胞迁移受损，肉芽肿形成加剧。

• 发表时间: 2005
• 期刊: J Immunol. 174
• 作者: Iizasa H;et al.
• 通讯作者: et al.

Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellula carcinoma : clinical safety.

经导管肝动脉栓塞与瘤内树突状细胞输注联合治疗肝细胞癌：临床安全性。

• 发表时间: 2007
• 期刊: Clin Exp Immunol. 147(2)
• 作者: Nakamoto Y;et al.
• 通讯作者: et al.

Tomita S, et al.: "T cell-specific disruption of aryl hydrocarbon receptor nuclear translocator gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution."J.Immunol.. 171. 4113-4120 (2003)

Tomita S 等人：“T 细胞特异性破坏芳基碳氢化合物受体核易位基因，导致对 2,3,7,8-四氯二苯并-对-二恶英诱导的胸腺退化产生抗性。”J.Immunol.. 171. 4113

Mobilization of Dendritic Cell Precursors Into the Circulation by Administration of MIP-1 a in Mice.

通过在小鼠中施用 MIP-1a 将树突状细胞前体动员到循环中。

• 发表时间: 2004
• 期刊: J Natl Cancer Inst. 96(3)
• 作者: Zhang Y;et al.
• 通讯作者: et al.