Microfluidics Quantum Diamond Sensor

微流控量子金刚石传感器

• 批准号: 499424854
• 负责人: Professor Dr. Fedor Jelezko
• 金额: --
• 依托单位: Institut für Quantenoptik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/499424854?language=en
• 关键词: Microfluidics; Quantum; Diamond; Sensor

The field of microfluidics has witnessed rapid growth in the recent years, and it is now ubiquitous in areas as diverse as biology, medicine, and chemistry. Today, microfluids are a paramount resource in blood testing, printing, and fuel cells, to cite but a few. The ability to estimate the main microfluid properties is crucial for the drug industry and in medicine where, for example, detection of free radicals in biological samples is critical to understanding processes such as the immune response. The most widespread platform, which has contributed to the greatest extent to the development of microfluidics is the Lab on a Chip approach to chemical and biological analysis. Since chips contain microfluid channels and integrated analysis tools, it is vital to have precise control over the physics of fluids in these microchannels. However, accumulating evidence has shown that the flow in these channels does not always obey macroscopic fluid laws, such as the no-slip boundary condition usually taken for granted when characterizing fluid properties. Though there have been advances in microscopic theory, a technology to accurately measure velocity has not yet been developed. This Mf-QDS presents a radically different approach to the measurement of velocity and diffusion properties in microfluid channels. Based on shallow Nitrogen Vacancy (NV) centers implanted in a diamond matrix positioned sufficiently close to the flowing liquid, we will use nano-NMR techniques to detect the statistical field produced by the nuclei in the vicinity of the NV. As the molecules flow through the channel, the magnetic noise induced in the NV fluctuates. Tracking these fluctuations as changes in the NV state will provide an unprecedented level of accuracy in terms of the velocity flow profile of the microfluid and its temperature, while making it possible to differentiate between several component species. None of these parameters can be achieved with current classical methods although they are vital for the next generation of microfluid devices. We will design and implement an integrated tool containing the diamond with the NVs and microfluid channels that can be exported to any microfluidic device, and provides a state of the art resolution capacity.

近年来，微流体领域发展迅速，现在在生物学、医学和化学等领域无处不在。今天，微流体是血液检测、打印和燃料电池等领域的重要资源。估计主要微流体特性的能力对于制药行业和医学至关重要，例如，生物样品中自由基的检测对于理解免疫反应等过程至关重要。 最广泛的平台，在最大程度上促进了微流体的发展，是化学和生物分析的芯片实验室方法。由于芯片包含微流体通道和集成分析工具，因此对这些微通道中的流体物理特性进行精确控制至关重要。然而，越来越多的证据表明，这些通道中的流动并不总是遵循宏观流体定律，例如在表征流体性质时通常认为是理所当然的无滑移边界条件。虽然在微观理论方面已经取得了进展，但尚未开发出精确测量速度的技术。 这种Mf-QDS提出了一种完全不同的方法来测量微流体通道中的速度和扩散特性。基于浅氮空位（NV）中心植入金刚石矩阵定位足够接近流动的液体，我们将使用纳米核磁共振技术来检测在NV附近的核产生的统计场。当分子流过通道时，在NV中诱导的磁噪声波动。跟踪这些波动作为NV状态的变化将在微流体的速度流动曲线及其温度方面提供前所未有的准确度，同时使得有可能区分几种组分种类。这些参数中没有一个可以用当前的经典方法来实现，尽管它们对于下一代微流体装置至关重要。我们将设计和实现一个集成工具，包含钻石与NVs和微流体通道，可以输出到任何微流体设备，并提供最先进的分辨率能力。