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New therapeutic strategies for treatment of cancer based on basic research

New therapeutic strategies for treatment of cancer based on basic research
基于基础研究的癌症治疗新策略
批准号:
16062101
负责人:
UEDA Ryuzo
金额:
$11.84万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2009

项目摘要

项目成果

UEDA Ryuzo的其他基金

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中文摘要
翻译
在这个项目中,我们的目标是利用癌症的基础知识,建立新的治疗癌症的策略。我们已经证明了去聚焦人源化抗ccr4抗体在成人t细胞白血病-淋巴瘤患者中的临床疗效,tgf - β受体抑制剂对胶质瘤起始细胞的有效性,以及FGF受体单克隆抗体对肝细胞癌的潜在应用。
英文摘要
In this project, we aimed to establish new therapeutic strategies for treatment of cancer, utilizing basic knowledge on cancer. We have shown the clinical efficacy of a defucosylated humanized anti-CCR4 antibody in patients with adult T-cell leukemia-lymphoma, effectiveness of TGF-beta receptor inhibitor on glioma-initiating cells, and potential use of FGF receptor monoclonal antibody to hepatocellular carcinoma.
期刊论文(70)
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会议论文
Nonmutated self-antigen-derived cancer vaccine peptides elicit an IgE-independent but mast cell-dependent immediate-type skin reaction without systemic anaphylaxis.
非突变自身抗原衍生的癌症疫苗肽可引发不依赖于 IgE 但依赖于肥大细胞的立即型皮肤反应,而不会产生全身性过敏反应。
DOI: --
发表时间: 2006
期刊: J Immunol. 176
影响因子: --
作者: [Yamada A., Itoh K et al.]
通讯作者: Itoh K et al.
DOI: 10.1016/j.ymthe.2004.07.015
发表时间: 2004-10-01
期刊: MOLECULAR THERAPY
影响因子: 12.4
作者: [Fumoto, S, Kawakami, S, Hashida, M]
通讯作者: Hashida, M
Defucosylated AntiCC Chemokine Receptor 4 Monoclonal Antibody Combined with Immunomodulatory Cytokines: A Novel Immnuotherapy for Aggressive/Refractory Mycosis Fungoides and Sezary Syndrome
去岩藻糖基化 AntiCC 趋化因子受体 4 单克隆抗体与免疫调节细胞因子联合:治疗侵袭性/难治性蕈样肉芽肿和塞扎里综合征的新型免疫疗法
DOI: --
发表时间: 2007
期刊: Clin Cancer Res 13(21)
影响因子: --
作者: [Yano, H.]
通讯作者: H.
DOI: 10.1021/bc0602329
发表时间: 2007-01-01
期刊: BIOCONJUGATE CHEMISTRY
影响因子: 4.7
作者: [Uehara, Tomoya, Koike, Miho, Arano, Yasushi]
通讯作者: Arano, Yasushi
34
    Development of comprehensive immunotherapy by defuccosylated antibody
    Development of novel treatment strategy against Hodgkin lymphoma based on the immunopathogenesis
    • 批准号:
      19390266
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.32万
    • 财政年份:
      2007
    • 负责人:
      UEDA Ryuzo
    • 依托单位:
    The scientific clinical study of antibody therapy
    • 批准号:
      17016065
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $133.82万
    • 财政年份:
      2005
    • 负责人:
      UEDA Ryuzo
    • 依托单位:
    Molecular-based study for the development of monoclonal antibody therapy in chemokine receptors, CCR4 and CXCR3
    • 批准号:
      16390280
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $7.36万
    • 财政年份:
      2004
    • 负责人:
      UEDA Ryuzo
    • 依托单位:
    海外基金