Development of novel treatment strategy against Hodgkin lymphoma based on the immunopathogenesis

基于免疫发病机制开发霍奇金淋巴瘤新治疗策略

• 批准号: 19390266
• 负责人: UEDA Ryuzo
• 金额: $ 11.32万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390266/
• 关键词: ホジキンリンパ腫; 腫瘍免疫; CCR4; EBウィルス; MUM1; IRF-4; EBウイルス

We have demonstrated that the anti-CCR4 mAb reduces the number of Treg cells among TIL in an in vivo NOG mouse model (bearing human tumor & engrafted with human immune cells). These results indicate that use of anti-CCR4 mAb could represent a novel strategy for the treatment not only of Hodgkin lymphoma, but also many other types of cancer by overcoming suppressive effects of Treg cells on the host's immune response to tumor cells. In the near future, the efficacy of the anti-CCR4 mAb in the latter context will also be established in clinical trials in humans.

我们已经证明，在体内 NOG 小鼠模型（携带人类肿瘤并植入人类免疫细胞）中，抗 CCR4 mAb 减少了 TIL 中 Treg 细胞的数量。这些结果表明，通过克服 Treg 细胞对宿主对肿瘤细胞的免疫反应的抑制作用，使用抗 CCR4 mAb 不仅可以代表治疗霍奇金淋巴瘤的新策略，而且可以代表治疗许多其他类型癌症的新策略。在不久的将来，抗 CCR4 mAb 在后一种情况下的功效也将在人体临床试验中得到证实。

项目成果

Anti-CCR4 monoclonal antibody as a novel therapy for advanced mycosis fungoides and Sezary syndrome

抗 CCR4 单克隆抗体作为晚期蕈样肉芽肿和塞扎里综合征的新疗法

• 发表时间: 2009
• 期刊: Rinsho Ketsueki 50(12)
• 作者: 越智俊元;安川正貴;他;Yano H
• 通讯作者: Yano H

Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerse I inhibitor, irinotecan (CPT- 11), for multiple myeloma

羧酸酯酶 2 的过度表达可增强拓扑异构酶 I 抑制剂伊立替康 (CPT-11) 对多发性骨髓瘤的疗效

• 发表时间: 2008
• 期刊: Cancer Sci. 99(11)
• 作者: Ohmura Y;Yoshikawa K;Saga S;Ueda R;Kazaoka Y;Yamada S.;Yano H
• 通讯作者: Yano H

Bortezomib-induced apoptosis in mature T-cell lymphoma cells partially depends on upregulation of Noxa and functional repression of Mcl-1

• DOI: 10.1111/j.1349-7006.2008.01038.x
• 发表时间: 2009-02-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Ri, Masaki;Iida, Shinsuke;Ueda, Ryuzo
• 通讯作者: Ueda, Ryuzo

Small-cell lung cancer arising after chemotherapy for a patient with lymphoma of pulmonary mucosa-associated lymphoid tissue-a case report

肺粘膜相关淋巴组织淋巴瘤化疗后发生小细胞肺癌1例报告

• 发表时间: 2009
• 期刊: Gan To Kagaku Ryoho 36(10)
• 作者: 越智俊元;安川正貴;他;Yano H;Kusumoto S;NaKao M
• 通讯作者: NaKao M

Phase I study of KW-0761, a Defucosylated Patients(Pts) with Adult T-Cell Leukemia-Lymphoma(ATLL) or Peripheral T-Cell Lymphoma(PTCL): Updated Results.

KW-0761（成人 T 细胞白血病淋巴瘤 (ATLL) 或外周 T 细胞淋巴瘤 (PTCL) 去岩藻糖基化患者 (Pts)）的 I 期研究：更新结果。

• 发表时间: 2008
• 作者: Yamamoto K;Tobinai K;Utsunomiya A;Tsukasaki K;Uike N;Uozumi K;Tomonaga M;Matsushima K;Shitara K;Akinaga S;Ueda R.
• 通讯作者: Ueda R.